Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871

• Published in: Journal of antibiotics Vol. 60; no. 4; pp. 277 - 284
• Main Authors: Graf, Ellen, Schneider, Kathrin, Nicholson, Graeme, Stroebele, Markus, Jones, Amanda L., Goodfellow, Michael, Beil, Winfried, Suessmuth, Roderich D., Fiedler, Hans-Peter
• Format: Journal Article
• Language: English
• Published: LONDON Springer Nature 01.04.2007; Nature Publishing Group
• Subjects: Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - isolation & purification; Antibiotics, Antineoplastic - pharmacology; Biotechnology & Applied Microbiology; Cell Cycle - drug effects; Cell Line, Tumor; Fermentation; Humans; Immunology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Microbiology; Oxazines - chemistry; Oxazines - isolation & purification; Oxazines - pharmacology; Pharmacology & Pharmacy; Science & Technology; Streptomyces griseus; Streptomyces griseus - classification; Streptomyces griseus - metabolism; Structure-Activity Relationship; APOPTOSIS; ANTIBIOTICS; antitumor activity; PHENAZINES; GROWTH; Streptomyces; FUNGUS PIGMENTS; taxonomy; structure elucidation; PHENOXAZINONES; aminophenoxazinones
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2007.35

Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.