Histological Alterations on the Structure of the Excretory Renal System in Tench (Tinca tinca) After Exposure to 17-Alpha-Ethynylestradiol

• Published in: Bulletin of environmental contamination and toxicology Vol. 91; no. 6; pp. 623 - 629
• Main Authors: Oropesa, A. L., Jiménez, B., Fallola, C., Pula, H. J., Cuesta, J. M., Gómez, L.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2013; Springer; Springer Nature B.V
• Subjects: Agnatha. Pisces; Animal, plant and microbial ecology; Animals; Applied ecology; Aquatic Pollution; Biological and medical sciences; Cells; Cyprinidae; Earth and Environmental Science; Ecotoxicology; Ecotoxicology, biological effects of pollution; Effects of pollution and side effects of pesticides on vertebrates; Environment; Environmental Chemistry; Environmental Health; Ethinyl Estradiol - toxicity; Freshwater; Fundamental and applied biological sciences. Psychology; Histology; Kidney - drug effects; Kidney - pathology; Kidneys; Lesions; Male; Pollution; Soil Science & Conservation; Tinca tinca; Waste Water Technology; Water Management; Water Pollutants, Chemical - toxicity; Water Pollution Control; Histophatology; 17-Alpha-ethynylestradiol; Kidney; Ethinylestradiol; Mimetic hormone; Renal function; Toxicity; Estrogen; Alteration; Endocrine disruptor; Tench; Freshwater environment; Pollutant; Tissue; Vertebrata; Sublethal dose; Histopathology; Pisces; Adult animal; Tinca tinca
• ISSN: 0007-4861; 1432-0800
• DOI: 10.1007/s00128-013-1088-2

This study describes the effects of 17-alpha-ethynylestradiol (EE 2 ) on the structure of the excretory system of the kidney in tench. Adult male tench were exposed to sub-lethal doses of EE 2 (50, 100 and 500 μg/kg b.w.) under semistatic conditions for a period of 30 days. The nephrosomatic index and histology (including a morphometric analysis) of the kidney were examined. Histopathological lesions in the kidney of exposed tench were: dilation of glomerular capillaries and increase in the area of the renal corpuscle, hyaline degeneration in the epithelial cells of the proximal tubules leading to necrotic changes, hemorrhages in the interstitial tissue and deposits of eosinophilic material. These lesions were observed with a greater degree of severity as the exposure doses were increased. These results indicate that long-term exposure to EE 2 could produce clear negative effects on the excretory system of the kidney in tench and consequently on their physiological functions.