Measuring levels of biogenic amines and their metabolites in rat brain tissue using high-performance liquid chromatography with photodiode array detection

We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 × 2.1 mm, 5 µm). The mobile phase was 5 mM perchloric ac...

Full description

Saved in:

Bibliographic Details
Published in	Archives of pharmacal research Vol. 39; no. 1; pp. 59 - 65
Main Authors	Gu, Min-Jung, Jeon, Ji-Hyun, Oh, Myung Sook, Hong, Seon-Pyo
Format	Journal Article
Language	English
Published	Seoul Pharmaceutical Society of Korea 2016 대한약학회
Subjects	acetonitrile Animals Biogenic Amines - analysis Biogenic Amines - metabolism brain Brain - metabolism Brain Chemistry Chromatography, High Pressure Liquid - methods correlation derivatization dopamine Dopamine - analysis Dopamine - metabolism high performance liquid chromatography homovanillic acid Male Medicine metabolites perchloric acid Pharmacology/Toxicology Pharmacy Rats Rats, Sprague-Dawley Research Article serotonin Serotonin - analysis Serotonin - metabolism 약학 Direct method Simultaneous determination Dopamine Serotonin HPLC–PDA Brain tissue
Online Access	Get full text
ISSN	0253-6269 1976-3786 1976-3786
DOI	10.1007/s12272-015-0661-0

Cover

Abstract	We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 × 2.1 mm, 5 µm). The mobile phase was 5 mM perchloric acid containing 5 % acetonitrile. The correlation coefficient was 0.9995–0.9999. LODs (S/N = 3) and LOQs (S/N = 10) were as follows: dopamine 0.4 and 1.3 pg, 3, 4-dihydroxyphenylacetic acid 8.4 and 28.0 pg, serotonin 0.4 and 1.3 pg, 5-hydroxyindolacetic acid 3.4 and 11.3 pg, and homovanillic acid 8.4 and 28.0 pg. This method does not require derivatization steps, and is more sensitive than the widely used HPLC–UV method.
AbstractList	We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 × 2.1 mm, 5 µm). The mobile phase was 5 mM perchloric acid containing 5 % acetonitrile. The correlation coefficient was 0.9995-0.9999. LODs (S/N = 3) and LOQs (S/N = 10) were as follows: dopamine 0.4 and 1.3 pg, 3, 4-dihydroxyphenylacetic acid 8.4 and 28.0 pg, serotonin 0.4 and 1.3 pg, 5-hydroxyindolacetic acid 3.4 and 11.3 pg, and homovanillic acid 8.4 and 28.0 pg. This method does not require derivatization steps, and is more sensitive than the widely used HPLC-UV method. We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 9 2.1 mm, 5 lm). The mobile phase was 5 mM perchloric acid containing 5 % acetonitrile. The correlation coefficient was 0.9995–0.9999. LODs (S/N = 3) and LOQs (S/N = 10) were as follows: dopamine 0.4 and 1.3 pg, 3, 4-dihydroxyphenylacetic acid 8.4 and 28.0 pg, serotonin 0.4 and 1.3 pg, 5-hydroxyindolacetic acid 3.4 and 11.3 pg, and homovanillic acid 8.4 and 28.0 pg. This method does not require derivatization steps, and is more sensitive than the widely used HPLC–UV method. KCI Citation Count: 0 We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 × 2.1 mm, 5 µm). The mobile phase was 5 mM perchloric acid containing 5 % acetonitrile. The correlation coefficient was 0.9995–0.9999. LODs (S/N = 3) and LOQs (S/N = 10) were as follows: dopamine 0.4 and 1.3 pg, 3, 4-dihydroxyphenylacetic acid 8.4 and 28.0 pg, serotonin 0.4 and 1.3 pg, 5-hydroxyindolacetic acid 3.4 and 11.3 pg, and homovanillic acid 8.4 and 28.0 pg. This method does not require derivatization steps, and is more sensitive than the widely used HPLC–UV method. We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 × 2.1 mm, 5 µm). The mobile phase was 5 mM perchloric acid containing 5 % acetonitrile. The correlation coefficient was 0.9995-0.9999. LODs (S/N = 3) and LOQs (S/N = 10) were as follows: dopamine 0.4 and 1.3 pg, 3, 4-dihydroxyphenylacetic acid 8.4 and 28.0 pg, serotonin 0.4 and 1.3 pg, 5-hydroxyindolacetic acid 3.4 and 11.3 pg, and homovanillic acid 8.4 and 28.0 pg. This method does not require derivatization steps, and is more sensitive than the widely used HPLC-UV method.We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 × 2.1 mm, 5 µm). The mobile phase was 5 mM perchloric acid containing 5 % acetonitrile. The correlation coefficient was 0.9995-0.9999. LODs (S/N = 3) and LOQs (S/N = 10) were as follows: dopamine 0.4 and 1.3 pg, 3, 4-dihydroxyphenylacetic acid 8.4 and 28.0 pg, serotonin 0.4 and 1.3 pg, 5-hydroxyindolacetic acid 3.4 and 11.3 pg, and homovanillic acid 8.4 and 28.0 pg. This method does not require derivatization steps, and is more sensitive than the widely used HPLC-UV method. We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a photodiode array detection. Measurements were made using a Hypersil Gold C-18 column (250 × 2.1 mm, 5 µm). The mobile phase was 5 mM perchloric acid containing 5 % acetonitrile. The correlation coefficient was 0.9995 – 0.9999. LODs (S / N = 3) and LOQs (S / N = 10) were as follows: dopamine 0.4 and 1.3 pg, 3, 4-dihydroxyphenylacetic acid 8.4 and 28.0 pg, serotonin 0.4 and 1.3 pg, 5-hydroxyindolacetic acid 3.4 and 11.3 pg, and homovanillic acid 8.4 and 28.0 pg. This method does not require derivatization steps, and is more sensitive than the widely used HPLC–UV method.
Author	Gu, Min-Jung Hong, Seon-Pyo Oh, Myung Sook Jeon, Ji-Hyun
Author_xml	– sequence: 1 fullname: Gu, Min-Jung – sequence: 2 fullname: Jeon, Ji-Hyun – sequence: 3 fullname: Oh, Myung Sook – sequence: 4 fullname: Hong, Seon-Pyo
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26463700$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002075455$$DAccess content in National Research Foundation of Korea (NRF)
BookMark	eNqFks1u1TAQRiNURG8LD8AGvIRFYGwnzs2yqvipVIQE7dpynEniNrFT2ym6r8LT4pDCgkXxZmzrnFnMfCfZkXUWs-wlhXcUoHofKGMVy4GWOQhBc3iS7WhdiZxXe3GU7YCVPBdM1MfZSQg3AFyUZfksO2aiELwC2GU_v6AKize2JyPe4xiI60hjXI_WaKImYzEQZVsSBzSeTBhV40YT06-xxKtIGq_SLZoQFiRLWDsNph_yGX3n_KSsRjKau8W0RA_eTSq63qt5OJAfJg5kHlx0rXEtEuW9OpAWI-ponH2ePe3UGPDFQz3Nrj9-uDr_nF9-_XRxfnaZ64KXMS8aCh3fF2VZcVY0uEfNG1FraKlGzhUw0WrF6rYVAqCpddGUrYL0LAC7Cvhp9nbra30nb7WRTpnftXfy1suzb1cXklIu9myf2DcbO3t3t2CIcjJB4zgqi24JkkE6jNe0_i9KK1FUUBSCJfTVA7o0E7Zy9mZS_iD_rCkBdAO0dyF47P4iFOQaBblFQaYoyDUKcnWqfxxtoloHG9PGxkdNtplhXoOBXt64xdu0g0el15vUKSdV702Q198Z0DRzKBIs-C8HZdLl
CitedBy_id	crossref_primary_10_1093_chromsci_bmaf004 crossref_primary_10_1016_j_apsusc_2021_151457 crossref_primary_10_3390_ijms19061560 crossref_primary_10_3390_ijms241814334 crossref_primary_10_1016_j_jpba_2018_02_025 crossref_primary_10_1038_s41434_023_00414_0 crossref_primary_10_1016_j_stem_2023_11_009 crossref_primary_10_1007_s10787_025_01661_w crossref_primary_10_1556_2060_2020_00036
Cites_doi	10.1111/j.1471-4159.1988.tb02935.x 10.2478/v10001-009-0012-9 10.1016/j.jchromb.2010.09.019 10.1016/S1570-0232(01)00612-2 10.1016/j.jpba.2004.09.029 10.1016/S0163-7258(98)00019-9 10.1093/brain/93.2.357 10.1002/jssc.201000799 10.1016/0378-4347(93)E0411-I 10.1016/j.jchromb.2003.12.006 10.1016/S0021-9673(03)00786-6 10.1016/j.jchromb.2006.09.032 10.1016/j.jchromb.2003.11.036 10.1016/0009-8981(84)90181-5 10.1016/j.chroma.2011.02.006 10.1016/S0021-9673(03)01180-4 10.1039/b008283j 10.1016/j.neuroscience.2010.04.080 10.1177/0269881108089597 10.1016/j.jchromb.2006.03.027 10.1248/bpb.31.2211 10.1093/clinchem/35.9.1975
ContentType	Journal Article
Copyright	The Pharmaceutical Society of Korea 2015
Copyright_xml	– notice: The Pharmaceutical Society of Korea 2015
DBID	FBQ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 ACYCR
DOI	10.1007/s12272-015-0661-0
DatabaseName	AGRIS CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic Korean Citation Index
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitleList	MEDLINE AGRICOLA MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher
DeliveryMethod	fulltext_linktorsrc
Discipline	Pharmacy, Therapeutics, & Pharmacology Medicine
EISSN	1976-3786
EndPage	65
ExternalDocumentID	oai_kci_go_kr_ARTI_1136828 26463700 10_1007_s12272_015_0661_0 US201600042276
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- -Y2 .86 .VR 06C 06D 0R~ 0VY 1N0 2.D 203 23N 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2VQ 2WC 2~H 30V 3SX 4.4 406 408 40D 40E 53G 5GY 5VS 67N 67Z 6J9 6NX 8TC 8UJ 95- 95. 95~ 96X 9ZL AAAVM AABHQ AACDK AAHBH AAHNG AAIAL AAJBT AAJKR AANXM AANZL AAPKM AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABDBE ABDZT ABECU ABFTV ABHQN ABJNI ABJOX ABKCH ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTKH ABTMW ABWNU ABXPI ACAOD ACBXY ACDTI ACGFO ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACREN ACSNA ACUDM ACZOJ ADHHG ADHIR ADHKG ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYOE ADZKW AEBTG AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFGCZ AFLOW AFQWF AFWTZ AFYQB AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHPBZ AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMTXH AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AYFIA AZFZN B-. BA0 BBWZM BDATZ BGNMA C1A CAG COF CS3 CSCUP DDRTE DNIVK DPUIP EBLON EBS EIOEI EJD EMOBN ESBYG F5P FBQ FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ7 GRRUI H13 HF~ HG6 HMJXF HRMNR HVGLF HZ~ IJ- IKXTQ IWAJR IXC IXD I~X I~Z J-C J0Z JBSCW JZLTJ KOV KPH KVFHK LLZTM M4Y MA- MZR N2Q N9A NDZJH NF0 NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OVD P19 P2P PF0 PT4 PT5 QOK QOR QOS R89 R9I RHV RNI RNS ROL RPX RSV RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SCLPG SDE SDH SHX SISQX SJN SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SZ9 SZN T13 T16 TEORI TSG TSK TUC U2A U9L UG4 UOJIU UTJUX UZXMN VC2 VFIZW W48 WK6 WK8 YLTOR Z45 ZMTXR ZOVNA ZZE ~A9 -53 -56 -5G -BR -EM -~C .UV ADINQ GQ6 Z7U Z7V Z7W Z83 Z87 Z8O Z8P Z8Q Z91 AAYXX ABBRH ABFSG ACMFV ACSTC AEZWR AFDZB AFHIU AFOHR AGQPQ AHWEU AIXLP ATHPR CITATION CGR CUY CVF ECM EIF NPM 7X8 ABRTQ 7S9 L.6 AABYN AAFGU AAKSU AAPBV AAYFA ABFGW ABKAS ACBMV ACBRV ACBYP ACIGE ACIPQ ACTTH ACVWB ACWMK ACYCR ADMDM ADOXG AEEQQ AEFTE AESTI AEVTX AFAFS AFNRJ AGGBP AGKHE AIMYW AJDOV AKQUC UNUBA Z7X
ID	FETCH-LOGICAL-c435t-4b10f384557324be8ec3b69c0d1ce33a026dca29dd6600b9c4b5da0dd640ef703
IEDL.DBID	AGYKE
ISSN	0253-6269 1976-3786
IngestDate	Tue Nov 21 21:30:00 EST 2023 Fri Sep 05 03:56:54 EDT 2025 Fri Sep 05 11:48:22 EDT 2025 Wed Feb 19 02:17:19 EST 2025 Thu Apr 24 23:03:27 EDT 2025 Tue Jul 01 03:46:53 EDT 2025 Fri Feb 21 02:37:04 EST 2025 Thu Apr 03 09:43:56 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Direct method Simultaneous determination Dopamine Serotonin HPLC–PDA Brain tissue
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c435t-4b10f384557324be8ec3b69c0d1ce33a026dca29dd6600b9c4b5da0dd640ef703
Notes	http://dx.doi.org/10.1007/s12272-015-0661-0 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 G704-000010.2016.39.1.011
PMID	26463700
PQID	1764704462
PQPubID	23479
PageCount	7
ParticipantIDs	nrf_kci_oai_kci_go_kr_ARTI_1136828 proquest_miscellaneous_2000023919 proquest_miscellaneous_1764704462 pubmed_primary_26463700 crossref_primary_10_1007_s12272_015_0661_0 crossref_citationtrail_10_1007_s12272_015_0661_0 springer_journals_10_1007_s12272_015_0661_0 fao_agris_US201600042276
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2016 20160100 2016-1-00 2016-Jan 20160101 2016-01
PublicationDateYYYYMMDD	2016-01-01
PublicationDate_xml	– year: 2016 text: 2016
PublicationDecade	2010
PublicationPlace	Seoul
PublicationPlace_xml	– name: Seoul – name: Korea (South)
PublicationTitle	Archives of pharmacal research
PublicationTitleAbbrev	Arch. Pharm. Res
PublicationTitleAlternate	Arch Pharm Res
PublicationYear	2016
Publisher	Pharmaceutical Society of Korea 대한약학회
Publisher_xml	– name: Pharmaceutical Society of Korea – name: 대한약학회
References	Zhao, Zhang, Yuan (CR23) 2001; 126 Fujino, Yoshitake, Kehr, Nohta, Yamaguchi (CR6) 2003; 1012 Syslová, Rambousek, Kuzma, Najmanová, Bubeníková-Valešová, Šlamberová, Kačer (CR20) 2011; 1218 Chen, Shi, Liu (CR5) 2003; 1003 Carrera, Sabater, Vilanova, Sogorb (CR4) 2007; 847 Liu, Li, Li, Ling, Liu, Wang, Sun, Chen, Bi (CR8) 2011; 34 Moir, Ashcroft, Crawford, Eccleston, Guldberg (CR9) 1970; 93 Nguyen, Aerts, Van Dam, De Deyn (CR13) 2010; 878 Young (CR22) 2007; 32 Törnkvist, Sjöberg, Markides, Bergquist (CR21) 2004; 801 Saxer, Niina, Nakashima, Nagae, Masuda (CR18) 2004; 802 Karimi, Carl, Loftin, Perlmutter (CR7) 2006; 836 Satoh, Nonaka, Ohashi, Shimizu, Oshio, Takeda (CR17) 2008; 31 Rondelli, Acerbi, Mariotti, Ventura (CR15) 1994; 653 Abeling, Gennip, Overmars, Voute (CR1) 1984; 137 Muthian, Mackey, King, Charlton (CR12) 2010; 169 Roth, Willins, Kristiansen, Kroeze (CR16) 1998; 79 Swiercz, Grzelinska, Gralewicz, Wasowicz (CR19) 2009; 22 Murai, Saito, Masuda, Itoh (CR10) 1988; 50 Cannazza, Di Stefano, Mosciatti, Braghiroli, Baraldi, Pinnen, Sozio, Benatti, Parenti (CR3) 2005; 36 Oliveira, Barrientos-Astigarraga, Sucupira, Graudenz, Muscará, Nucci (CR14) 2002; 768 Ardis, Cahir, Elliott, Bell, Reynolds, Cooper (CR2) 2009; 23 Musso, Vergassola, Pende, Lotti (CR11) 1989; 35 TC Ardis (661_CR2) 2009; 23 K Fujino (661_CR6) 2003; 1012 NG Abeling (661_CR1) 1984; 137 L Liu (661_CR8) 2011; 34 S Murai (661_CR10) 1988; 50 CH Oliveira (661_CR14) 2002; 768 A Törnkvist (661_CR21) 2004; 801 M Karimi (661_CR7) 2006; 836 I Rondelli (661_CR15) 1994; 653 R Swiercz (661_CR19) 2009; 22 ATB Moir (661_CR9) 1970; 93 G Muthian (661_CR12) 2010; 169 AT Nguyen (661_CR13) 2010; 878 H Zhao (661_CR23) 2001; 126 SN Young (661_CR22) 2007; 32 C Saxer (661_CR18) 2004; 802 G Cannazza (661_CR3) 2005; 36 K Satoh (661_CR17) 2008; 31 BL Roth (661_CR16) 1998; 79 K Syslová (661_CR20) 2011; 1218 NR Musso (661_CR11) 1989; 35 V Carrera (661_CR4) 2007; 847 J Chen (661_CR5) 2003; 1003
References_xml	– volume: 50 start-page: 473 issue: 2 year: 1988 end-page: 479 ident: CR10 article-title: Rapid determination of norepinephrine, dopamine, serotonin, their precursor amino acids, and related metabolites in discrete brain areas of mice within ten minutes by HPLC with electrochemical detection publication-title: Journal of Neurochemistry doi: 10.1111/j.1471-4159.1988.tb02935.x – volume: 35 start-page: 1975 issue: 9 year: 1989 end-page: 1977 ident: CR11 article-title: Reversed-phase HPLC separation of plasma norepinephrine, epinephrine, and dopamine, with three-electrode coulometric detection publication-title: Clinical Chemistry – volume: 22 start-page: 107 issue: 2 year: 2009 end-page: 113 ident: CR19 article-title: Catecholamine levels in the brain of rats exposed by inhalation to benzalkonium chloride publication-title: International Journal of Occupational Medicine and Environmental Health doi: 10.2478/v10001-009-0012-9 – volume: 878 start-page: 3003 year: 2010 end-page: 3014 ident: CR13 article-title: Biogenic amines and their metabolites in mouse brain tissue: Development, optimization and validation of an analytical HPLC method publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2010.09.019 – volume: 768 start-page: 341 year: 2002 end-page: 348 ident: CR14 article-title: Quantification of methyldopa in human plasma by high-performance liquid chromatography-electrospray tandem mass spectrometry: Application to a bioequivalence study publication-title: Journal of Chromatography B doi: 10.1016/S1570-0232(01)00612-2 – volume: 36 start-page: 1079 issue: 5 year: 2005 end-page: 1084 ident: CR3 article-title: Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC publication-title: Journal of Pharmaceutical and Biomedical Analysis doi: 10.1016/j.jpba.2004.09.029 – volume: 79 start-page: 231 issue: 3 year: 1998 end-page: 257 ident: CR16 article-title: 5-Hydroxytryptamine -family receptors (5-hydroxytryptamine , 5-hydroxytryptamine , 5-hydroxytryptamine ): where structure meets function publication-title: Pharmacology & Therapeutics doi: 10.1016/S0163-7258(98)00019-9 – volume: 93 start-page: 357 year: 1970 end-page: 368 ident: CR9 article-title: Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain publication-title: Brain doi: 10.1093/brain/93.2.357 – volume: 32 start-page: 394 issue: 6 year: 2007 end-page: 399 ident: CR22 article-title: How to increase serotonin in the human brain without drugs publication-title: Journal of Psychiatry and Neuroscience – volume: 34 start-page: 1198 issue: 10 year: 2011 end-page: 1204 ident: CR8 article-title: Simultaneous determination of catecholamines and their metabolites related to Alzheimer’s disease in human urine publication-title: Journal of Separation Science doi: 10.1002/jssc.201000799 – volume: 653 start-page: 17 year: 1994 end-page: 23 ident: CR15 article-title: Simultaneous determination of levodopa methyl ester, 3- -methyldopa and dopamine in plasma by high-performance liquid chromatography with electrochemical detection publication-title: Journal of Chromatography B doi: 10.1016/0378-4347(93)E0411-I – volume: 802 start-page: 299 year: 2004 end-page: 305 ident: CR18 article-title: Simultaneous determination of levodopa and 3- -methyldopa in human plasma by liquid chromatography with electrochemical detection publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2003.12.006 – volume: 1003 start-page: 127 year: 2003 end-page: 132 ident: CR5 article-title: Determination of noradrenaline and dopamine in Chinese herbal extracts from L. by high-performance liquid chromatography publication-title: Journal of Chromatography A doi: 10.1016/S0021-9673(03)00786-6 – volume: 847 start-page: 88 year: 2007 end-page: 94 ident: CR4 article-title: A simple and rapid HPLC-MS method for the simultaneous determination of epinephrine, norepinephrine, dopamine and 5-hydroxy tryptamine: Application to the secretion of bovine chromaffin cell cultures publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2006.09.032 – volume: 801 start-page: 323 year: 2004 end-page: 329 ident: CR21 article-title: Analysis of catecholamines and related substances using porous graphitic carbon as separation media in liquid chromatography-tandem mass spectrometry publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2003.11.036 – volume: 137 start-page: 211 issue: 2 year: 1984 end-page: 226 ident: CR1 article-title: Simultaneous determination of catecholamines and metanephrines in urine by HPLC with fluorometric detection publication-title: Clinica Chimica Acta doi: 10.1016/0009-8981(84)90181-5 – volume: 1218 start-page: 3382 year: 2011 end-page: 3391 ident: CR20 article-title: Monitoring of dopamine and its metabolites in brain microdialysates: Method combining freeze-drying with liquid chromatography–tandem mass spectrometry publication-title: Journal of Chromatography A doi: 10.1016/j.chroma.2011.02.006 – volume: 1012 start-page: 169 issue: 2 year: 2003 end-page: 177 ident: CR6 article-title: Simultaneous determination of 5-hydroxyindoles and catechols by high-performance liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine publication-title: Journal of Chromatography A doi: 10.1016/S0021-9673(03)01180-4 – volume: 126 start-page: 358 issue: 3 year: 2001 end-page: 360 ident: CR23 article-title: Electrochemical determination of dopamine using a poly (2-picolinic acid) modified glassy carbon electrode publication-title: Analyst doi: 10.1039/b008283j – volume: 169 start-page: 1085 issue: 3 year: 2010 end-page: 1093 ident: CR12 article-title: Modeling a sensitization stage and a precipitation stage for parkinson’s disease using prenatal and postnatal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.04.080 – volume: 23 start-page: 51 issue: 1 year: 2009 end-page: 55 ident: CR2 article-title: Effect of acute tryptophan depletion on noradrenaline and dopamine in the rat brain publication-title: Journal of Psychopharmacology doi: 10.1177/0269881108089597 – volume: 836 start-page: 120 year: 2006 end-page: 123 ident: CR7 article-title: Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3- -methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2006.03.027 – volume: 31 start-page: 2211 issue: 12 year: 2008 end-page: 2215 ident: CR17 article-title: The effects of in Utero exposure to a migrant, 4,4′-butylidenebis(6-t-butyl-m-cresol), from nitrile-butadiene rubber gloves on monoamine neurotransmitter in rats publication-title: Biological &/and Pharmaceutical Bulletin doi: 10.1248/bpb.31.2211 – volume: 1012 start-page: 169 issue: 2 year: 2003 ident: 661_CR6 publication-title: Journal of Chromatography A doi: 10.1016/S0021-9673(03)01180-4 – volume: 36 start-page: 1079 issue: 5 year: 2005 ident: 661_CR3 publication-title: Journal of Pharmaceutical and Biomedical Analysis doi: 10.1016/j.jpba.2004.09.029 – volume: 93 start-page: 357 year: 1970 ident: 661_CR9 publication-title: Brain doi: 10.1093/brain/93.2.357 – volume: 79 start-page: 231 issue: 3 year: 1998 ident: 661_CR16 publication-title: Pharmacology & Therapeutics doi: 10.1016/S0163-7258(98)00019-9 – volume: 768 start-page: 341 year: 2002 ident: 661_CR14 publication-title: Journal of Chromatography B doi: 10.1016/S1570-0232(01)00612-2 – volume: 50 start-page: 473 issue: 2 year: 1988 ident: 661_CR10 publication-title: Journal of Neurochemistry doi: 10.1111/j.1471-4159.1988.tb02935.x – volume: 23 start-page: 51 issue: 1 year: 2009 ident: 661_CR2 publication-title: Journal of Psychopharmacology doi: 10.1177/0269881108089597 – volume: 32 start-page: 394 issue: 6 year: 2007 ident: 661_CR22 publication-title: Journal of Psychiatry and Neuroscience – volume: 802 start-page: 299 year: 2004 ident: 661_CR18 publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2003.12.006 – volume: 847 start-page: 88 year: 2007 ident: 661_CR4 publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2006.09.032 – volume: 801 start-page: 323 year: 2004 ident: 661_CR21 publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2003.11.036 – volume: 31 start-page: 2211 issue: 12 year: 2008 ident: 661_CR17 publication-title: Biological &/and Pharmaceutical Bulletin doi: 10.1248/bpb.31.2211 – volume: 34 start-page: 1198 issue: 10 year: 2011 ident: 661_CR8 publication-title: Journal of Separation Science doi: 10.1002/jssc.201000799 – volume: 126 start-page: 358 issue: 3 year: 2001 ident: 661_CR23 publication-title: Analyst doi: 10.1039/b008283j – volume: 1003 start-page: 127 year: 2003 ident: 661_CR5 publication-title: Journal of Chromatography A doi: 10.1016/S0021-9673(03)00786-6 – volume: 169 start-page: 1085 issue: 3 year: 2010 ident: 661_CR12 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.04.080 – volume: 22 start-page: 107 issue: 2 year: 2009 ident: 661_CR19 publication-title: International Journal of Occupational Medicine and Environmental Health doi: 10.2478/v10001-009-0012-9 – volume: 878 start-page: 3003 year: 2010 ident: 661_CR13 publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2010.09.019 – volume: 1218 start-page: 3382 year: 2011 ident: 661_CR20 publication-title: Journal of Chromatography A doi: 10.1016/j.chroma.2011.02.006 – volume: 137 start-page: 211 issue: 2 year: 1984 ident: 661_CR1 publication-title: Clinica Chimica Acta doi: 10.1016/0009-8981(84)90181-5 – volume: 35 start-page: 1975 issue: 9 year: 1989 ident: 661_CR11 publication-title: Clinical Chemistry doi: 10.1093/clinchem/35.9.1975 – volume: 836 start-page: 120 year: 2006 ident: 661_CR7 publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2006.03.027 – volume: 653 start-page: 17 year: 1994 ident: 661_CR15 publication-title: Journal of Chromatography B doi: 10.1016/0378-4347(93)E0411-I
SSID	ssj0036555
Score	2.1568115
Snippet	We developed a method to detect biogenic amines and their metabolites in rat brain tissue using simultaneous high-performance liquid chromatography and a...
SourceID	nrf proquest pubmed crossref springer fao
SourceType	Open Website Aggregation Database Index Database Enrichment Source Publisher
StartPage	59
SubjectTerms	acetonitrile Animals Biogenic Amines - analysis Biogenic Amines - metabolism brain Brain - metabolism Brain Chemistry Chromatography, High Pressure Liquid - methods correlation derivatization dopamine Dopamine - analysis Dopamine - metabolism high performance liquid chromatography homovanillic acid Male Medicine metabolites perchloric acid Pharmacology/Toxicology Pharmacy Rats Rats, Sprague-Dawley Research Article serotonin Serotonin - analysis Serotonin - metabolism 약학
Title	Measuring levels of biogenic amines and their metabolites in rat brain tissue using high-performance liquid chromatography with photodiode array detection
URI	https://link.springer.com/article/10.1007/s12272-015-0661-0 https://www.ncbi.nlm.nih.gov/pubmed/26463700 https://www.proquest.com/docview/1764704462 https://www.proquest.com/docview/2000023919 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002075455
Volume	39
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
ispartofPNX	Archives of Pharmacal Research, 2016, 39(1), , pp.59-65
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9NAEF6RVEJceBRozSMaEOoB6spvx8cUNRRQqkokUjmt1rvr1EpqB9s5hJ_Cr2XGj0ZAi9RLokhrZ1f77ey3OzPfMPYuCZRMEp2Yeuhp0xORbcbKlqbQAW4OQuOuQInCk7PgdOZ9ufAv2jzusot271yStaXeJrs5TkhhBD5lzeMZuMd2fHsYDftsZ_Tp-9eTzgC7gV8XO8Xd3DWRr0edM_Oml_yxHfUSkeNnViQ38c1_fKX1FjR-xKZd55vIk8XRuoqP5M-_dB3vOLrH7GFLSWHUYOgJu6ezXXZ_0jrdd9nBeSNvvTmE6TZbqzyEAzjfCl9vnrJfk_rCEf8WlhSLVEKeQJzmiNFUgriiCHsQmYLaOwFXukIEUg50CWkGCEWIqWAFVDUYgELy50B6yuZqm94Ay_THOlUgL4sc2XaruA10nwyry7zKVZorDaIoxAaUrupQs-wZm41Pph9Pzbb2gymRwFWmF9tW4g493w-R8sV6qKUbB5G0EEjadQUeHZUUTqRUgJQtjqQX-0pY-NOzdIJm7DnrZ3mm9xloR0vLCwVRLS-xpZAWvgWZmBspVyptMKuDAJetMDrV51jyraQzTQ7HyeE0Odwy2PvrR1aNKsj_Gu8jrriYo9Xms28OafrV0mthYLC3CDa-kCknmW_6nud8UXA8zHzmVG4HD8QGe9NhkePaJ4eOyHS-LrkdBl5IHnnn9jaUikUJzHZksL0GyNddRjIcuKGFPfzQgZK3Jqy8fTwv7tT6JXtAI25urV6xflWs9WvkcVU8wHU7Pj4-G7Trd8B6M2f0G8_nQLI
linkProvider	Springer Nature
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9NAEF7RVAIuPMqj4Tkg1APUlR9rOz5WqCWlTVWJRCqn1Xp3nVpJ7WA7h_BT-LXM-NEIaJF6iRVpbe9qP898uzPzLWMfkkCrJDGJZQbcWFxGjhVrR1nSBOgcpEGvQIXCo9NgOOFfz_3zto677LLdu5BkbanXxW6uG1IagU9V87gG3mCbHJfgdo9t7n_5fnzQGWAv8OvDTtGbexby9agLZl73kD_c0UYic_zNiuQ6vvlPrLR2QYcP2bjrfJN5MttbVvGe-vmXruMtR_eIPWgpKew3GHrM7phsi90dtUH3LbZz1shbr3ZhvK7WKndhB87WwterJ-zXqN5wxNfCnHKRSsgTiNMcMZoqkJeUYQ8y01BHJ-DSVIhAqoEuIc0AoQgxHVgBVQ0GoJT8KZCesrVYlzfAPP2xTDWoiyJHtt0qbgPtJ8PiIq9ynebagCwKuQJtqjrVLHvKJocH489Dqz37wVJI4CqLx46deAPu-yFSvtgMjPLiIFI2Asl4nsSlo1bSjbQOkLLFkeKxr6WNf7ltEjRjz1gvyzOzzcC4Rtk8lES1eOIoqWx8CjIxL9Ke0qbP7A4CQrXC6HQ-x1ysJZ1pcgROjqDJEXaffby6ZdGogvyv8TbiSsgpWm0x-eaSpl8tvRYGffYewSZmKhUk803XaS5mhcDFzJGg43ZwQdxn7zosCvz2KaAjM5MvS-GEAQ8pIu_e3IZKsaiA2Yn67HkD5KsuIxkOvNDGHn7qQClaE1bePJ4Xt2r9lt0bjkcn4uTo9Pglu0-jb3awXrFeVSzNa-R0Vfym_YZ_AzIcQSo
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9NAEF7RIlVcKiiPmueAUA9Qq347PlZA1AKpItFIva3W-0itpt5gO4f8FX4tM340QrRIXGxZWttrzXjm252Zbxh7bxIljdHG1aNIu5HIfDdXvnSFTtA5CI1egQqFJ2fJySz6ehFf9H1O6yHbfQhJdjUNxNJUNkdLZY42hW9BkFJKQUwV9Lge3mL30Rr7pOiz4HgwxWESt21P0a-HLiL3bAhr3vaIPxzTlhEWj2VlbkOef0VNW2c0fsh2exQJx53YH7F7utxjO5M-Tr7HDqYdI_X6EM43BVb1IRzAdMNVvX7Mfk3aPUJ8CSwofagGayAvLKpVIUFcU1I8iFJBG1CAa92g0lDZcg1FCag9kFOPCWha-QFl0c-BKJDd5aYiARbFz1WhQF5WFgFyT5INtAUMy0vbWFVYpUFUlViD0k2bHVY-YbPxl_NPJ27frsGViLkaN8p9z4SjKI5TRGm5HmkZ5kkmPZS9DkOBqz0lRZAplSDKyjMZ5bESHl5GnjZoeZ6y7dKWep-BDrT0olQQOoqML4X08CkInsJMhVJph3mDrLjsucyppcaCb1iYSbwcxctJvNxz2IebW5Ydkce_Bu-jAnAxR0PLZz8CouFr2dLSxGHvUCv4lSw4MXPTeW75VcVx_XHKqUMOrmEd9nZQGo6_K8VgRKntquZ-mkQpBdGDu8dQ9RTVHPuZw551GnczZcSvSZh6OMOPgwry3urUd3_P8_8a_YbtTD-P-ffTs28v2AP6-G7P6SXbbqqVfoUorMlft3_abxopKK4
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Measuring+levels+of+biogenic+amines+and+their+metabolites+in+rat+brain+tissue+using+high-performance+liquid+chromatography+with+photodiode+array+detection&rft.jtitle=Archives+of+pharmacal+research&rft.au=Gu%2C+Min-Jung&rft.au=Jeon%2C+Ji-Hyun&rft.au=Oh%2C+Myung+Sook&rft.au=Hong%2C+Seon-Pyo&rft.date=2016&rft.pub=Pharmaceutical+Society+of+Korea&rft.issn=0253-6269&rft.volume=39&rft.issue=1&rft.spage=59&rft.epage=65&rft_id=info:doi/10.1007%2Fs12272-015-0661-0&rft.externalDocID=US201600042276
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0253-6269&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0253-6269&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0253-6269&client=summon