Risk factors for local recurrence of middle and lower rectal carcinoma after curative resection

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 30; pp. 4805 - 4809
• Main Authors: Wu, Ze-Yu, Wan, Jin, Zhao, Gang, Peng, Lin, Du, Jia-Lin, Yao, Yuan, Liu, Quan-Fang, Lin, Hua-Huan
• Format: Journal Article
• Language: English
• Published: United States Department of General Surgery,Guangdong Provincial People's Hospital,Guangzhou 510080,Guangdong Province,China%Department of Pathology,Guangdong Provincial People's Hospital,Guangzhou 510080,Guangdong Province,China 14.08.2008; The WJG Press and Baishideng
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoembryonic Antigen - analysis; Carcinoma - immunology; Carcinoma - pathology; Carcinoma - surgery; Cell Differentiation; Digestive System Surgical Procedures - adverse effects; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Pedigree; Rapid Communication; Rectal Neoplasms - immunology; Rectal Neoplasms - pathology; Rectal Neoplasms - surgery; Risk Factors; Treatment Outcome; 中低位直肠癌; 局部切除术; 手术治疗; 肿瘤转移; Mesorectal metastasis; Circumferential resection margin; Local recurrence; Middle and lower rectal carcinoma
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.4805

AIM： To explore the risk factors for local recurrence of middle and lower rectal carcinoma after curative resection. METHODS： Specimens of middle and lower rectal carcinoma from 56 patients who received curative resection at the Department of General Surgery of Guangdong Provincial People＇s Hospital were studied. A large slice technique was used to detect mesorectal metastasis and evaluate circumferential resection margin status. The relations between clinicopathologic characteristics, mesorectal metastasis and circumferential resection margin status were identified in patients with local recurrence of middle and lower rectal carcinoma. RESULTS： Local recurrence of middle and lower rectal carcinoma after curative resection occurred in 7 of the 56 patients （12.5%）, and was significantly associated with family history （Х^2= 3.929, P = 0.047）, high CEA level （Х^2 = 4.964, P = 0.026）, cancerous perforation （Х^2 = 8.503, P = 0.004）, tumor differentiation （Х^2 = 9.315, P = 0.009） and vessel cancerous emboli （Х^2 = 11.879, P = 0.001）. In contrast, no significant correlation was found between local recurrence of rectal carcinoma and other variables such as age （Х^2 = 0.506, P = 0.477）, gender （Х^2 = 0.102, Z2 = 0.749）, tumor diameter （Х^2 = 0.421, P = 0.516）,tumor infiltration （Х^2 = 5.052, P = 0.168）, depth of tumor invasion （Х^2 = 4.588, P = 0.101）, lymph node metastases （Х^2 = 3.688, P = 0.055） and TNM staging system （Х^2 = 3.765, P = 0.152）. The local recurrence rate of middle and lower rectal carcinoma was 33.3% （4/12） in patients with positive circumferential resection margin and 6.8% （3/44） in those with negative circumferential resection margin. There was a significant difference between the two groups （Х^2 = 6.061, P = 0.014）. Local recurrence of rectal carcinoma occurred in 6 of 36 patients （16.7%） with mesorectal metastasis, and in 1 of 20 patients （5.0%） without mesorectal metastasis. However, there was no significant difference between the two groups （Х^2 = 1.600, P = 0.206）. CONCLUSION： Family history, high CEA level, cancerous perforation, tumor differentiation, vessel cancerous emboli and circumferential resection margin status are the significant risk factors for local recurrence of middle and lower rectal carcinoma after curative resection. Local recurrence may be more frequent in patients with mesorectal metastasis than in patients without mesorectal metastasis.