The Association Between the Triglyceride Glucose Index and Hyperuricemia: A Dose–Response Meta-Analysis

Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. Methods: This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databas...

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Published inNutrients Vol. 17; no. 9; p. 1462
Main Authors Wang, Juan, He, Qiang, Sun, Wenhui, Li, Wei, Yang, Yuting, Cui, Weiwei, Yang, Xiangshan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.04.2025
MDPI
Subjects
Adult
Blood Glucose - analysis
Blood Glucose - metabolism
Body mass index
Dextrose
Diabetes
Estimates
Female
Gender
Glucose
Heart
Humans
Hypertension
Hyperuricemia
Hyperuricemia - blood
Insulin resistance
Liu, Timothy
Male
Meta-analysis
Metabolic disorders
Middle Aged
Overweight
Risk Factors
Triglycerides
Triglycerides - blood
Uric acid
Uric Acid - blood
United States
China
United States > US
dose–response meta-analysis
hyperuricemia
triglyceride glucose index
Online AccessGet full text
ISSN2072-6643
2072-6643
DOI10.3390/nu17091462

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Abstract Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. Methods: This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databases, from the launch date until March 2025. The effect sizes and corresponding 95% confidence intervals (CIs) were obtained using a random effects model. Results: Twenty-six trials with 637,954 subjects were incorporated in this study. It was revealed that the TyG index was linked to hyperuricemia (OR = 2.67; 95% CI: 2.34, 3.04; p < 0.001). A dose–response analysis demonstrated that with each 1 mg/dL rise in the TyG index, the risk of being diagnosed with hyperuricemia increased by 2.07 times (OR = 2.07; 95% CI: 1.89, 2.25; p < 0.001). Conclusions: The TyG index has an association with hyperuricemia. Given the constraints identified in our meta-analysis, further cohort studies will be essential to confirm this correlation.
AbstractList Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. Methods: This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databases, from the launch date until March 2025. The effect sizes and corresponding 95% confidence intervals (CIs) were obtained using a random effects model. Results: Twenty-six trials with 637,954 subjects were incorporated in this study. It was revealed that the TyG index was linked to hyperuricemia (OR = 2.67; 95% CI: 2.34, 3.04; p < 0.001). A dose–response analysis demonstrated that with each 1 mg/dL rise in the TyG index, the risk of being diagnosed with hyperuricemia increased by 2.07 times (OR = 2.07; 95% CI: 1.89, 2.25; p < 0.001). Conclusions: The TyG index has an association with hyperuricemia. Given the constraints identified in our meta-analysis, further cohort studies will be essential to confirm this correlation.
The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databases, from the launch date until March 2025. The effect sizes and corresponding 95% confidence intervals (CIs) were obtained using a random effects model. Twenty-six trials with 637,954 subjects were incorporated in this study. It was revealed that the TyG index was linked to hyperuricemia (OR = 2.67; 95% CI: 2.34, 3.04; < 0.001). A dose-response analysis demonstrated that with each 1 mg/dL rise in the TyG index, the risk of being diagnosed with hyperuricemia increased by 2.07 times (OR = 2.07; 95% CI: 1.89, 2.25; < 0.001). The TyG index has an association with hyperuricemia. Given the constraints identified in our meta-analysis, further cohort studies will be essential to confirm this correlation.
Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. Methods: This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databases, from the launch date until March 2025. The effect sizes and corresponding 95% confidence intervals (CIs) were obtained using a random effects model. Results: Twenty-six trials with 637,954 subjects were incorporated in this study. It was revealed that the TyG index was linked to hyperuricemia (OR = 2.67; 95% CI: 2.34, 3.04; p < 0.001). A dose-response analysis demonstrated that with each 1 mg/dL rise in the TyG index, the risk of being diagnosed with hyperuricemia increased by 2.07 times (OR = 2.07; 95% CI: 1.89, 2.25; p < 0.001). Conclusions: The TyG index has an association with hyperuricemia. Given the constraints identified in our meta-analysis, further cohort studies will be essential to confirm this correlation.Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. Methods: This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databases, from the launch date until March 2025. The effect sizes and corresponding 95% confidence intervals (CIs) were obtained using a random effects model. Results: Twenty-six trials with 637,954 subjects were incorporated in this study. It was revealed that the TyG index was linked to hyperuricemia (OR = 2.67; 95% CI: 2.34, 3.04; p < 0.001). A dose-response analysis demonstrated that with each 1 mg/dL rise in the TyG index, the risk of being diagnosed with hyperuricemia increased by 2.07 times (OR = 2.07; 95% CI: 1.89, 2.25; p < 0.001). Conclusions: The TyG index has an association with hyperuricemia. Given the constraints identified in our meta-analysis, further cohort studies will be essential to confirm this correlation.
Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. Methods: This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databases, from the launch date until March 2025. The effect sizes and corresponding 95% confidence intervals (CIs) were obtained using a random effects model. Results: Twenty-six trials with 637,954 subjects were incorporated in this study. It was revealed that the TyG index was linked to hyperuricemia (OR = 2.67; 95% CI: 2.34, 3.04; p < 0.001). A dose–response analysis demonstrated that with each 1 mg/dL rise in the TyG index, the risk of being diagnosed with hyperuricemia increased by 2.07 times (OR = 2.07; 95% CI: 1.89, 2.25; p < 0.001). Conclusions: The TyG index has an association with hyperuricemia. Given the constraints identified in our meta-analysis, further cohort studies will be essential to confirm this correlation.
Audience Academic
Author Cui, Weiwei
He, Qiang
Li, Wei
Wang, Juan
Sun, Wenhui
Yang, Yuting
Yang, Xiangshan
AuthorAffiliation 2 Department of Radiation Hygiene, School of Public Health, Jilin University, Changchun 130021, China; heq@jlu.edu.cn
1 Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, China; wangjuan23@mails.jlu.edu.cn (J.W.); sunwh23@mails.jlu.edu.cn (W.S.); liw23@mails.jlu.edu.cn (W.L.); ytyang23@mails.jlu.edu.cn (Y.Y.); cuiweiwei@jlu.edu.cn (W.C.)
AuthorAffiliation_xml – name: 2 Department of Radiation Hygiene, School of Public Health, Jilin University, Changchun 130021, China; heq@jlu.edu.cn
– name: 1 Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, China; wangjuan23@mails.jlu.edu.cn (J.W.); sunwh23@mails.jlu.edu.cn (W.S.); liw23@mails.jlu.edu.cn (W.L.); ytyang23@mails.jlu.edu.cn (Y.Y.); cuiweiwei@jlu.edu.cn (W.C.)
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hyperuricemia
triglyceride glucose index
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RelatedPersons Liu, Timothy
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Snippet Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject...
The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of...
Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject...
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SubjectTerms Adult
Blood Glucose - analysis
Blood Glucose - metabolism
Body mass index
Dextrose
Diabetes
Estimates
Female
Gender
Glucose
Heart
Humans
Hypertension
Hyperuricemia
Hyperuricemia - blood
Insulin resistance
Liu, Timothy
Male
Meta-analysis
Metabolic disorders
Middle Aged
Overweight
Risk Factors
Triglycerides
Triglycerides - blood
Uric acid
Uric Acid - blood
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Title The Association Between the Triglyceride Glucose Index and Hyperuricemia: A Dose–Response Meta-Analysis
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