The Association Between the Triglyceride Glucose Index and Hyperuricemia: A Dose–Response Meta-Analysis

• Published in: Nutrients Vol. 17; no. 9; p. 1462
• Main Authors: Wang, Juan, He, Qiang, Sun, Wenhui, Li, Wei, Yang, Yuting, Cui, Weiwei, Yang, Xiangshan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.04.2025; MDPI
• Subjects: Adult; Blood Glucose - analysis; Blood Glucose - metabolism; Body mass index; Dextrose; Diabetes; Estimates; Female; Gender; Glucose; Heart; Humans; Hypertension; Hyperuricemia; Hyperuricemia - blood; Insulin resistance; Liu, Timothy; Male; Meta-analysis; Metabolic disorders; Middle Aged; Overweight; Risk Factors; Triglycerides; Triglycerides - blood; Uric acid; Uric Acid - blood; United States; China; United States > US; dose–response meta-analysis; hyperuricemia; triglyceride glucose index
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu17091462

Background: The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. Methods: This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databases, from the launch date until March 2025. The effect sizes and corresponding 95% confidence intervals (CIs) were obtained using a random effects model. Results: Twenty-six trials with 637,954 subjects were incorporated in this study. It was revealed that the TyG index was linked to hyperuricemia (OR = 2.67; 95% CI: 2.34, 3.04; p < 0.001). A dose–response analysis demonstrated that with each 1 mg/dL rise in the TyG index, the risk of being diagnosed with hyperuricemia increased by 2.07 times (OR = 2.07; 95% CI: 1.89, 2.25; p < 0.001). Conclusions: The TyG index has an association with hyperuricemia. Given the constraints identified in our meta-analysis, further cohort studies will be essential to confirm this correlation.