Size does not determine the grade of malignancy of early invasive colorectal cancer

AIM: To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers (EI-CRCs), and to determine whether malignancy grade depends on size. METHODS: A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Cen...

Full description

Saved in:
Bibliographic Details
Published inWorld journal of gastroenterology : WJG Vol. 15; no. 22; pp. 2708 - 2713
Main Authors Matsuda, Takahisa, Saito, Yutaka, Fujii, Takahiro, Uraoka, Toshio, Nakajima, Takeshi, Kobayashi, Nozomu, Emura, Fabian, Ono, Akiko, Shimoda, Tadakazu, Ikematsu, Hiroaki, Fu, Kuang I, Sano, Yasushi, Fujimori, Takahiro
Format Journal Article
LanguageEnglish
Published United States Endoscopy Division,National Cancer Center Hospital,Tokyo 104-0045,Japan%Clinical Laboratory Division,National Cancer Center Hospital,Tokyo 104-0045,Japan%Division of Digestive Endoscopy and Gastrointestinal Oncology,National Cancer Center Hospital East,Kashiwa 277-8577,Japan%Department of Surgical and Molecular Pathology,Dokkyo University School of Medicine,Shimotsuga,Tochigi 321-0293,Japan 14.06.2009
The WJG Press
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:AIM: To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers (EI-CRCs), and to determine whether malignancy grade depends on size. METHODS: A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between 1980 and 2004 were enrolled in this study. Lesions were classified into two groups based on size: small (≤10 ram) and large (〉10 ram). Clinicopathological features, incidence of lymph node metastasis (LNM) and risk factors for LNM, such as depth of invasion, lymphovascular invasion (LVI) and poorly differentiated adenocarcinoma (PDA) were analyzed in all resected specimens. RESULTS: There were 120 (21%) small and 463 (79%) large lesions. Histopathological analysis of the small lesion group revealed submucosal deep cancer (sin: 1〉1000 μm) in 90 (75%) cases, LVI in 26 (22%) cases, and PDA in 12 (10%) cases. Similarly, the large lesion group exhibited submucosal deep cancer in 380 (82%) cases, LVI in 125 (27%) cases, and PDA in 79 (17%) cases. The rate of LNM was 11.2% and 12.1% in the small and large lesion groups, respectively.CONCLUSION: Small EI-CRC demonstrated the same aggressiveness and malignant potential as large cancer.
Bibliography:Lymph node metastasis
Submucosal invasion
14-1219/R
Colorectal cancer
Endoscopic mucosal resection
TP368.33
Q64
Colorectal cancer; Submucosal invasion; Lymph node metastasis; Endoscopic mucosal resection
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Correspondence to: Takahisa Matsuda, MD, Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. tamatsud@ncc.go.jp
Author contributions: Matsuda T, Saito Y and Fujii T contributed equally to this work; Matsuda T, Uraoka T, Nakajima T and Kobayashi N designed the research; Matsuda T, Ikematsu H, Fu KI and Sano Y performed the research; Shimoda T and Fujimori T performed the histopathology; Matsuda T, Saito Y, Emura F and Ono A wrote the paper.
Fax: +81-3-35423815
Telephone: +81-3-35422511
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.15.2708