Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats

• Published in: Brain research bulletin Vol. 98; pp. 10 - 22
• Main Authors: Frías-Domínguez, Carmen, Garduño, Julieta, Hernández, Salvador, Drucker-Colin, René, Mihailescu, Stefan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2013
• Subjects: 5-HT1A receptor; Aconitine - analogs & derivatives; Aconitine - pharmacology; Action Potentials - drug effects; Adrenalectomy; Animals; Corticosterone; Corticosterone - blood; Dihydro-beta-Erythroidine - pharmacology; Dorsal raphe nucleus; Dose-Response Relationship, Drug; Male; Neural Inhibition - drug effects; Neurology; Nicotine; Nicotine - pharmacology; Nicotinic Agonists - pharmacology; Nicotinic Antagonists - pharmacology; Piperazines - pharmacology; Pyridines - pharmacology; Raphe Nuclei - cytology; Raphe Nuclei - drug effects; Rats; Rats, Wistar; Serotonergic Neurons - drug effects; Serotonin; Serotonin - metabolism; Serotonin - pharmacology; Serotonin Antagonists - pharmacology; nAChRs; DRN; Serotonin; Adx + CSR rats; Corticosterone; Dorsal raphe nucleus; adrenalectomised and corticosterone-treated rats; nicotinic acetylcholine receptors; 5-HT1A receptor; Nicotine; Adx+CSR rats
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2013.07.006

Highlights • Adrenalectomised and chronic corticosterone rats had flat corticosterone plasma levels. • In corticosterone treated rats, nicotine inhibited the firing of 5-HT dorsal raphe neurons. • In corticosterone treated rats nicotine and 5-HT increase IKIR. • Nicotine seems to induced 5-HT release in the dorsal raphe nucleus. • Nicotine effects are mediated by α4β2 nicotinic receptors.