Correlation Between Angiotensin Receptor Type 1 Polymorphisms and Atherosclerotic Cerebral Infarction Risk

• Published in: Pharmacogenomics and personalized medicine Vol. 15; pp. 477 - 485
• Main Authors: Chen, Linfa, Wang, Ying, Wang, Yajun, Huang, Shaoting, Wu, Zhaochun, He, Jiawen, Zhong, Wangtao, Zhao, Bin, Ma, Guoda, Li, You
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 31.05.2022; Dove; Dove Medical Press
• Subjects: angiotensin receptor type 1; atherosclerotic cerebral infarction; case-control; Genes; Genetic polymorphisms; Hypertension; Original Research; polymorphism; China; atherosclerotic cerebral infarction; polymorphism; case-control; angiotensin receptor type 1
• ISSN: 1178-7066; 1178-7066
• DOI: 10.2147/PGPM.S364648

Emerging evidences suggest that the angiotensin receptor type 1 (AT1R) contributes heavily to the pathogenesis of atherosclerotic cerebral infarction (ACI). Herein, we examined a potential link between AT1R gene polymorphisms and ACI risk among a Southern Han Chinese population. The rs3772616, rs275645, and rs377262 AT1R polymorphisms were genotyped in 689 ACI patients and 712 healthy controls, using the iMLDR-TM assay. The genotypic and allelic frequencies of AT1R rs3772616 differed tremendously between ACI patients and healthy controls, and the rs3772616 T allele is a risk allele for ACI. However, the rs275645 and rs377262 allelic and genotypic frequency distributions were comparable between ACI patients and controls. In addition, the G-T-T haplotype was linked to an enhanced risk of ACI. We, next, classified our study subjects based on environmental factors and revealed that the rs3772616 T allele was strongly associated with an elevated ACI risk in males, hypertensive individuals, and those over 65 years old. In addition, we observed a marked link between the rs3772616 T allele and enhanced AT1R levels. Based on our research, there is a strong correlation between the AT1R rs3772616 polymorphism and enhanced ACI risk. Hence, the AT1R rs3772616 polymorphism can serve as a potential therapeutic target and bioindicator for ACI development.