A story of liver and gut microbes: how does the intestinal flora affect liver disease? A review of the literature

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 318; no. 5; pp. G889 - G906
• Main Authors: Giuffrè, Mauro, Campigotto, Michele, Campisciano, Giuseppina, Comar, Manola, Crocè, Lory Saveria
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.05.2020
• Subjects: Digestive system; Gastrointestinal tract; Immunomodulation; Intestinal microflora; Intestine; Literature reviews; Liver diseases; Microbiota; Microorganisms; Mucosa; fecal transplantation; chronic liver diseases; gut-liver axis; oral microbiota; gut-brain-liver axis; microbiome; liver cirrhosis; dysbiosis; probiotics
• ISSN: 0193-1857; 1522-1547; 1522-1547
• DOI: 10.1152/ajpgi.00161.2019

Each individual is endowed with a unique gut microbiota (GM) footprint that mediates numerous host-related physiological functions, such as nutrient metabolism, maintenance of the structural integrity of the gut mucosal barrier, immunomodulation, and protection against microbial pathogens. Because of increased scientific interest in the GM, its central role in the pathophysiology of many intestinal and extraintestinal conditions has been recognized. Given the close relationship between the gastrointestinal tract and the liver, many pathological processes have been investigated in the light of a microbial-centered hypothesis of hepatic damage. In this review we introduce to neophytes the vast world of gut microbes, including prevalent bacterial distribution in healthy individuals, how the microbiota is commonly analyzed, and the current knowledge of the role of GM in liver disease pathophysiology. Also, we highlight the potentials and downsides of GM-based therapy.