Nodular liver lesions involving multiple myeloma： A case report and literature review

• Published in: World journal of gastroenterology : WJG Vol. 15; no. 8; pp. 1014 - 1017
• Main Authors: Wu, Xiao-Ning, Zhao, Xin-Yan, Jia, Ji-Dong
• Format: Journal Article
• Language: English
• Published: United States Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China 28.02.2009; The WJG Press and Baishideng
• Subjects: Bone Neoplasms - pathology; Bone Neoplasms - secondary; Case Report; Female; Humans; Immunoglobulin kappa-Chains - analysis; Immunoglobulin Light Chains - analysis; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Middle Aged; Multiple Myeloma - pathology; Ultrasonography; 丙型肝炎病毒; 多发性骨病变; 多发性骨髓瘤; 文献复习; 病例报告; 结节性病变; 肝癌病灶; 血清蛋白; Nodular lesions; IgA kappa light chain; Hepatitis C virus; Liver; Multiple myeloma
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.15.1014

We report a case of a 62-year old woman admitted to our hospital for multiple nodular metastatic liver lesions found by ultrasonography in a regular medical examination. Routine laboratory tests were normal. PET-CT showed multiple bone lesions and nodular liver lesions. Liver biopsy revealed nodular infiltration of multiple myeloma with positive staining of kappa light chain. Further investigation of bone marrow aspiration, immunofixation and immunoelectrophoresis of serum protein, urine test for Bence-Jones protein, 132-microglobulin in serum and urine confirmed the diagnosis. The patient also coinfected with hepatitis C virus （HCV）. With six cycles of chemotherapy with VAD schedule, she achieved complete remission. In this report, a literature review of liver lesions involving multiple myeloma is also provided.