New-Onset Alzheimer’s Disease and Normal Subjects 100% Differentiated by P300

• Published in: American journal of Alzheimer's disease and other dementias Vol. 34; no. 5; pp. 308 - 313
• Main Authors: Jervis, B. W., Bigan, C., Jervis, M. W., Besleaga, M.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.08.2019
• Subjects: Aged; Alzheimer Disease - diagnosis; Alzheimer Disease - physiopathology; Cerebral Cortex - physiopathology; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - physiopathology; Current Topics in Research; Electroencephalography - methods; Event-Related Potentials, P300 - physiology; Evoked Potentials, Auditory - physiology; Female; Humans; Male; Models, Theoretical; Neural Networks, Computer; artificial neural network; PSFAM; Alzheimer’s disease; biomarkers; P300; Bayes classifier; independent components analysis; auditory-evoked potential
• ISSN: 1533-3175; 1938-2731
• DOI: 10.1177/1533317519828101

Previous work has suggested that evoked potential analysis might allow the detection of subjects with new-onset Alzheimer’s disease, which would be useful clinically and personally. Here, it is described how subjects with new-onset Alzheimer’s disease have been differentiated from healthy, normal subjects to 100% accuracy, based on the back-projected independent components (BICs) of the P300 peak at the electroencephalogram electrodes in the response to an oddball, auditory-evoked potential paradigm. After artifact removal, clustering, selection, and normalization processes, the BICs were classified using a neural network, a Bayes classifier, and a voting strategy. The technique is general and might be applied for presymptomatic detection and to other conditions and evoked potentials, although further validation with more subjects, preferably in multicenter studies is recommended.