Therapeutic effect of traditional Chinese medicine on coagulation disorder and accompanying intractable jaundice in hepatitis B virus-related liver cirrhosis patients

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 39; pp. 6060 - 6064
• Main Authors: Li, Yang-Mei, Yang, Hong-Zhi, Guan, Wei-Bing, Ke, Qian-Shan, Dai, Min, Xie, He-Ping, Zhang, Shi-Jun
• Format: Journal Article
• Language: English
• Published: United States Department of TCM, The Third Affiliated Hospital of Sun Yat-Sen University, 600# Tianhe Road, Guangzhou 510630, Guangdong Province, China%Department of TCM, The First Affiliated Hospital of Sun Yat-Sen University, 58# Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China 21.10.2008; The WJG Press and Baishideng
• Subjects: Adult; Bilirubin - metabolism; Blood Circulation - physiology; Blood Coagulation - physiology; Blood Coagulation Disorders - etiology; Blood Coagulation Disorders - physiopathology; Blood Coagulation Disorders - therapy; Female; Fibrinogen - metabolism; Hepatitis B - complications; Hepatitis B virus; Humans; Jaundice - etiology; Jaundice - metabolism; Jaundice - therapy; Liver Cirrhosis - complications; Liver Cirrhosis - virology; Male; Medicine, Chinese Traditional - methods; Middle Aged; Prothrombin Time; Rapid Communication; Retrospective Studies; Treatment Outcome; 中医治疗; 治疗方法; 病理机制; 肝纤维化; 西医治疗; Combination of traditional Chinese and Western medicine; Nourishing yin; Cooling blood and invigorating blood circulation; Liver cirrhosis; Coagulationdisorder
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.6060

AIM： TO observe the therapeutic effects of new traditional Chinese medicine （TClVl） therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients. METHODS： Using stratified random sampling according to fibrinogen （Fib） levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by ＂nourishing yin, cooling blood and invigorating blood circulation＂ and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared. RESULTS： The prothrombin time （PT） was shorter and the fibrinogen （Fib） level was higher in the research group than in the control group （Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and ≤ 1.0 g/L）. The total bilirubin （TBIL） level was significantly lower in the research group than in the control group, except for the subgroup of FIB ≤ 1.0 g/L. CONCLUSION： TCM therapy can improve coagulation fuction and decrease TBIL.