Challenges to pneumococcal vaccine in India

• Published in: Indian journal of medical microbiology Vol. 31; no. 1; pp. 1 - 2
• Main Author: Kanungo, R
• Format: Journal Article
• Language: English
• Published: India Elsevier B.V 01.01.2013; Medknow Publications; Elsevier Limited
• Subjects: Alliances; Antibiotics; Bacterial infections; Child, Preschool; Demography; Disease; Drug resistance; Epidemiology; Health Policy; Humans; Immunization; Immunization Schedule; India - epidemiology; Laboratories; Molecular Typing; Pneumococcal Infections - epidemiology; Pneumococcal Infections - microbiology; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - administration & dosage; Pneumococcal Vaccines - immunology; Pneumonia; Serotyping; Streptococcus infections; Streptococcus pneumoniae - classification; Streptococcus pneumoniae - isolation & purification; Vaccines; India
• ISSN: 0255-0857; 1998-3646
• DOI: 10.4103/0255-0857.108701

[1] Impact of vaccination and replacement disease by non-vaccine serotypes needs to be monitored closely.Would the current antibiotic susceptibility pattern change in the non-vaccine serotypes? PCR in culture-negative pneumococcal empyema due to prior antibiotic treatment has clearly established the role of non-vaccine type in the aetiology [7]Limitations of the conjugate vaccine need to be overcome by exploring other virulence factors that may have potential advantages. [8] suggest 'that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines'.A review on vaccine impact on pneumococcal disease by Keith P. Klugman [9] highlights several pertinent issues, which are: a) Role of children in transmitting infections to the adult vulnerable population, especially those with HIV. b) Nasopharynx as a niche for carriage of multiple serotypes as documented by post-5-PCV program in Gambia and 9-PCV in Sweto, South Africa.