STUDIES ON THE ADENOVIRUS AS AN ETIOLOGICAL AGENT OF PHARYNGOCONJUNCTIVAL FEVER

• Published in: Japanese Journal of Medical Science and Biology Vol. 10; no. 2; pp. 79 - 85
• Main Authors: FUKUMI, HIDEO, NISHIKAWA, FUMIO, NAKAMURA, KENJI, WATANABE, TEIKICHI, KITAYAMA, TORU, FUJITA, CHIKAYO
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 1957
• Subjects: Adenoviridae; Adenoviridae Infections; Humans; Old Medline; ADENOVIRUS INFECTIONS
• ISSN: 0021-5112; 1884-2828
• DOI: 10.7883/yoken1952.10.79

Since the adenovirus (Bell, Dingle, Francis, Hilleman, Huebner and Payne, 1956) had been independently discovered by three groups of workers (Rowe, Huebner, Gilmore, Parrott and Ward, 1953; Hilleman and Werner, 1954; Neva and Enders, 1954), a variety of disease states were found to be associated with this new group of viruses, namely acute respiratory diseases (ARD) (Hilleman and Werner, 1954; Hilleman, Werner, Dascomb and Butler, 1955; Hilleman, Werner, Adair and Dreisbach, 1955; Berge, England, Mauris, Shuey and Len-nette, 1955), primary atypical pneumonia (Hilleman and Werner, 1954; Hille-man, Werner, Adair and Dreisbach, 1955) pharyngoconjunctival fever (Bell, Rowe, Engler, Parrott and Huebner, 1955; Parrott, Rowe, Huebner, Bernton and McCullough, 1954), an exanthematous fever (Neva and Enders, 1954), and epidemic keratoconjunctivitis (Jawetz, Kimura, Hannd, Coleman, Thygeson and Nicholas 1955) . We have been looking for infections of adenovirus since 1955 by using HeLa cells and encountered four cases of pharyngoconjunctival fever confirmed to be due to adenovirus among those who visited the pediatric clinic of Ka.nta Communication Hospital for examination. The present paper is dedicated to describe these cases together with the types of adenovirus isolated from them and, in addition, a preliminary serological survey for adenovirus.