Glucose and zinc concentration influence fusarin C synthesis, ethanol synthesis and lipid composition in Fusarium moniliforme submerged cultures

• Published in: FEMS microbiology letters Vol. 108; no. 1; pp. 69 - 73
• Main Authors: Jackson, M.A, Lanser, A.C
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 15.03.1993; Blackwell
• Subjects: Biological and medical sciences; biosynthesis; Biotechnology; Ethanol - metabolism; ethanol production; Fatty acid composition; fatty acids; Fatty Acids - chemistry; Fatty Acids - metabolism; Fundamental and applied biological sciences. Psychology; fusarins; Fusarium - drug effects; Fusarium - metabolism; Fusarium moniliforme; Gibberella fujikuroi; glucose; Glucose - pharmacology; Lipid Metabolism; Lipids - chemistry; Microbiology; Mocytoxin; Morphology, structure, chemical composition; Mycology; nutrient deficiencies; nutrient-nutrient interactions; Oleic acid; Polyenes - metabolism; Polyketide; Stearic acid; zinc; Zinc - pharmacology; Culture medium; Ethanol; Mycotoxin; Lipids; Environmental factor; Biosynthesis; Glucose; Fatty acids; Zinc; Fungi; Toxin; Submerged culture; Chemical composition; Fungi Imperfecti; Fusarium moniliforme; Thallophyta
• ISSN: 0378-1097; 1574-6968
• DOI: 10.1111/j.1574-6968.1993.tb06075.x

A fusarin C-producing Fusarium moniliforme strain was grown in submerged culture with defined media containing differing amounts of glucose (30 g/l or 90 g/l) and zinc (5 ppb or 3200 ppb). The influence of zinc on fusarin C synthesis and lipid composition was dependent on the initial glucose concentration. In cultures supplied with 30 g/l glucose, zinc inhibited fusarin C and lipid synthesis by diverting common substrates to ethanol synthesis. Zinc-supplemented cultures with 90 g/l glucose had ample carbon substrate to produce both ethanol and fusarin C. More total lipid with a higher unsaturated fatty acid content (more oleic acid and less stearic acid) was found in F. moniliforme biomass produced in zinc-deficient media.