Oestrogen and progesterone receptors in lentigo maligna

We have measured oestrogen and progesterone binding in specimens of histopathologically confirmed lentigo maligna (LM) lesions excised from five elderly white men, using a dextran-coated charcoal method. Oestrogen binding was observed in four of the five specimens, and progesterone binding in all fi...

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Bibliographic Details
Published inBritish journal of dermatology (1951) Vol. 118; no. 1; p. 69
Main Authors Sawaya, M E, Garland, L D, Rothe, M J, Honig, L S, Hsia, S L
Format Journal Article
LanguageEnglish
Published England 01.01.1988
Subjects
Aged
Humans
Lentigo - metabolism
Male
Middle Aged
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Skin - analysis
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Summary:We have measured oestrogen and progesterone binding in specimens of histopathologically confirmed lentigo maligna (LM) lesions excised from five elderly white men, using a dextran-coated charcoal method. Oestrogen binding was observed in four of the five specimens, and progesterone binding in all five. Marginal normal skin showed only non-specific binding for oestrogen and progesterone. The presence of steroid hormone receptors in LM suggests the possibility that hormone responsiveness may be relevant in the transformation of a lentigo maligna into malignant melanoma.
ISSN:0007-0963
DOI:10.1111/j.1365-2133.1988.tb01751.x