HLA-DR2 and white matter lesion distribution in MS

Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnet...

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Published inJournal of neuroimaging Vol. 18; no. 3; p. 328
Main Authors Sepulcre, Jorge, Masdeu, Joseph C, Palacios, Ricardo, Goñi, Joaquín, Moreno, Beatriz, Tainta, Mikel, Bejarano, Bartolomé, Villoslada, Pablo
Format Journal Article
LanguageEnglish
Published United States 01.07.2008
Subjects
Adult
Female
Genotype
HLA-DR2 Antigen - genetics
HLA-DR2 Antigen - immunology
Humans
Image Processing, Computer-Assisted
Linear Models
Magnetic Resonance Imaging
Male
Multiple Sclerosis - genetics
Multiple Sclerosis - immunology
Phenotype
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Summary:Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnetic resonance imaging (MRI). On a voxel-by-voxel basis, we analyzed the T1 and T2 MRI-derived lesion maps of 50 patients with MS in order to determine the possible influence of HLA-DR2 genotype on the lesional MRI pattern at early stages of the disease. HLA-DR2 was present in 15 (30%) patients of our cohort. They displayed similar WM lesion distribution as the subjects without this factor. Thus, lesion distribution in MS seems to be independent of the DR2 genotype.
ISSN:1552-6569
DOI:10.1111/j.1552-6569.2008.00259.x