New insights into the exercise intolerance of β-thalassemia major patients
The purpose of our study was assessment of the relative contribution of the systems involved in blood gas exchange to the limited exercise capacity in patients with β‐thalassemia major (TM) using integrative cardiopulmonary exercise testing (CPET) with estimation of oxygen kinetics. The study consis...
Saved in:
Published in | Scandinavian journal of medicine & science in sports Vol. 19; no. 1; pp. 96 - 102 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.2009
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The purpose of our study was assessment of the relative contribution of the systems involved in blood gas exchange to the limited exercise capacity in patients with β‐thalassemia major (TM) using integrative cardiopulmonary exercise testing (CPET) with estimation of oxygen kinetics. The study consisted of 15 consecutive TM patients and 15 matched controls who performed spirometric evaluation, measurement of maximum inspiratory pressure (Pimax) and an incremental symptom‐limited CPET on a cycle ergometer. Exercise capacity was markedly reduced in TM patients as assessed by peak oxygen uptake (pVO2, mL/kg/min: 22.1±6.6 vs 33.8±8.3; P<0.001) and anaerobic threshold (mL/kg/min: 13.0±3.0 vs 18.7±4.6; P<0.001) compared with controls. No ventilatory limitation to exercise was noted in TM patients (VE/VCO2 slope: 23.4±3.2 vs 27.8±2.6; P<0.001 and breathing reserve, %: 42.9±17.0 vs 29.5±12.0; P<0.005) and no difference in oxygen cost of work (peak VO2/WR, mL/min W: 12.2±1.7 vs 12.2±1.5; P=NS). Delayed recovery oxygen kinetics after exercise was observed in TM patients (VO2/t slope, mL/kg/min2: 0.67±0.27 vs 0.93±0.23; P<0.05) that was significantly correlated with Pimax at rest (r: 0.81; P<0.001). The latter was also significantly correlated to pVO2 (r: 0.84; P<0.001) and inversely correlated to ferritin levels (r: −0.6; P<0.02). Exercise capacity is markedly reduced in TM patients and this reduction is highly associated with the limited functional status of peripheral muscles. |
---|---|
Bibliography: | istex:E01F83862DA7FE474A1D0508BAE654A9B57438C2 ArticleID:SMS778 ark:/67375/WNG-G5JT31MD-X ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0905-7188 1600-0838 |
DOI: | 10.1111/j.1600-0838.2008.00778.x |