Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications

• Published in: Journal of applied polymer science Vol. 137; no. 25
• Main Authors: Uman, Selen, Dhand, Abhishek, Burdick, Jason A.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 05.07.2020; Wiley Subscription Services, Inc
• Subjects: Biomedical engineering; Biomedical materials; drug delivery; Drug delivery systems; Electrostatics; Healing; Hydrogels; Hydrogen bonds; Hydrophobicity; Imines; Injectability; injectable hydrogels; Materials science; Nanocomposites; Polymers; Polypeptides; self‐healing; Shear; shear‐thinning; Thinning; Three dimensional printing; Tissue engineering; Viscous flow
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.48668

ABSTRACT Shear‐thinning and self‐healing hydrogels are being investigated in various biomedical applications including drug delivery, tissue engineering, and 3D bioprinting. Such hydrogels are formed through dynamic and reversible interactions between polymers or polypeptides that allow these shear‐thinning and self‐healing properties, including physical associations (e.g., hydrogen bonds, guest–host interactions, biorecognition motifs, hydrophobicity, electrostatics, and metal–ligand coordination) and dynamic covalent chemistry (e.g., Schiff base, oxime chemistry, disulfide bonds, and reversible Diels–Alder). Their shear‐thinning properties allow for injectability, as the hydrogel exhibits viscous flow under shear, and their self‐healing nature allows for stabilization when shear is removed. Hydrogels can be formulated as uniform polymer and polypeptide assemblies, as hydrogel nanocomposites, or in granular hydrogel form. This review focuses on recent advances in shear‐thinning and self‐healing hydrogels that are promising for biomedical applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48668.