Enaminones: Exploring Additional Therapeutic Activities
Enaminones, enamines of β‐dicarbonyl compounds, have been known for many years. Their early use has been relegated to serving as synthetic intermediates in organic synthesis and of late, in pharmaceutical development. Recently, the therapeutic potential of these entities has been realized. This revi...
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Published in | Journal of pharmaceutical sciences Vol. 96; no. 10; pp. 2509 - 2531 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Elsevier Inc
01.10.2007
Wiley Subscription Services, Inc., A Wiley Company Wiley American Pharmaceutical Association |
Subjects | |
Online Access | Get full text |
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Summary: | Enaminones, enamines of β‐dicarbonyl compounds, have been known for many years. Their early use has been relegated to serving as synthetic intermediates in organic synthesis and of late, in pharmaceutical development. Recently, the therapeutic potential of these entities has been realized. This review provides the background and current research in this area with emphasis of these agents as potential anticonvulsants, their proposed mechanisms of action, and as potential modulators of multidrug resistance (MDR). © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2509–2531, 2007 |
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Bibliography: | ark:/67375/WNG-4HWV23G1-T istex:F26AAC7D954FFF1B5D1A76A88D06B045E230A1D8 ArticleID:JPS20967 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0022-3549 1520-6017 |
DOI: | 10.1002/jps.20967 |