Keratocystic odontogenic tumors and Carnoy's solution: results and complications assessment

• Published in: Oral diseases Vol. 18; no. 6; pp. 548 - 557
• Main Authors: Ribeiro Junior, O, Borba, AM, Alves, CAF, de Gouveia, MM, Coracin, FL, Guimarães Júnior, J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2012; Wiley Subscription Services, Inc
• Subjects: Acetic Acid - adverse effects; Acetic Acid - therapeutic use; Adolescent; Adult; Aged; Carnoy's solution; Child; Chloroform - adverse effects; Chloroform - therapeutic use; Combined Modality Therapy; complications; Dentistry; Ethanol - adverse effects; Ethanol - therapeutic use; Female; Fixatives - adverse effects; Follow-Up Studies; Humans; Male; Mandibular Fractures - etiology; Mandibular Neoplasms - drug therapy; Mandibular Neoplasms - surgery; Mandibular Nerve - drug effects; Mandibular Nerve - physiopathology; Maxillary Neoplasms - drug therapy; Maxillary Neoplasms - surgery; Medical research; Middle Aged; Neoplasm Recurrence, Local - pathology; neuropathy; odontogenic cysts; odontogenic tumors; Odontogenic Tumors - drug therapy; Odontogenic Tumors - surgery; Osteotomy - adverse effects; Paresthesia - etiology; Postoperative Complications; Retrospective Studies; retrospective study; Surgical Wound Dehiscence - etiology; Surgical Wound Infection - etiology; Thermosensing - physiology; Time Factors; Touch - physiology; Trigeminal Nerve Injuries - etiology; Women; Young Adult
• ISSN: 1354-523X; 1601-0825
• DOI: 10.1111/j.1601-0825.2012.01907.x

Oral Diseases (2012) 18, 548–557 Objective:  Keratocystic odontogenic tumors (KOTs) can be treated with Carnoy’s solution, although this treatment modality is not free from complications. It is important to verify the incidence of complications after the use of Carnoy’s solution and compare these with the literature. Materials and methods:  This study verified the effects of a complementary treatment for KOTs and assessed the incidence of such complications as recurrence, infection, sequestrum formation, mandibular fracture, dehiscence, and neuropathy. Results:  Twenty‐two KOTs treated with Carnoy’s solution combined with peripheral ostectomy were included, and the follow‐up period varied from 12 to 78 months with a mean of 42.9 months. Complications included recurrence (4.5%), dehiscence (22.7%), infection (4.5%), and paresthesia (18.2%). No difference was found among lesions associated (9.1%) or not (0%) with nevoid basal cell carcinoma syndrome (P > 0.05). Dehiscence was influenced by marsupialization (P < 0.05), and paresthesia was observed exclusively in cases of mandibular canal fenestration (P < 0.01). Conclusions:  Complementary treatment with Carnoy’s solution and peripheral ostectomy appear to provide efficient treatment for KOTs. Complications originating from the use of the solution are less frequent and less serious than complications associated with cryotherapy. Neuropathy seems to be related to direct contact between the solution and the epineurium.