The occurrence of IgA pemphigus foliaceus without neutrophilic infiltration

A 70-year-old woman with pemphigus foliaceus is reported. Direct immunofluorescence performed on perilesional skin revealed deposits of IgA, C3 and lambda chains in the intercellular substance of the upper stratum spinosum. Indirect immunofluorescence demonstrated serum antibodies of the IgA class a...

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Published inClinical and experimental dermatology Vol. 19; no. 1; p. 56
Main Authors Neumann, E, Dmochowski, M, Bowszyc, J, Bowszyc-Dmochowska, M, Raptis, M
Format Journal Article
LanguageEnglish
Published England 01.01.1994
Subjects
Aged
Female
Humans
Immunoglobulin A - analysis
Neutrophils - pathology
Pemphigus - immunology
Pemphigus - pathology
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Summary:A 70-year-old woman with pemphigus foliaceus is reported. Direct immunofluorescence performed on perilesional skin revealed deposits of IgA, C3 and lambda chains in the intercellular substance of the upper stratum spinosum. Indirect immunofluorescence demonstrated serum antibodies of the IgA class against the intercellular region of the upper epidermis at an initial titre of 1:2560. Histological studies, performed together with immunofluorescence, revealed an absence of a distinct neutrophil infiltrate either in the epidermis or dermis, contrary to the findings in cases with intra-epidermal IgA deposits reported previously.
ISSN:0307-6938
DOI:10.1111/j.1365-2230.1994.tb01117.x