Usefulness of combined measurement of serum bile acids and ferritin as additional prognostic markers to predict failure to reach sustained response to antiviral treatment in chronic hepatitis C

• Published in: Journal of gastroenterology and hepatology Vol. 20; no. 4; pp. 547 - 554
• Main Authors: JORQUERA, FRANCISCO, MONTE, MARIA J, GUERRA, JOSE, SANCHEZ-CAMPOS, SONIA, MERAYO, JOSE A, OLCÓZ, JOSE L, GONZÁLEZ-GALLEGO, JAVIER, MARIN, JOSE J G
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01.04.2005; Blackwell Science
• Subjects: Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Antiviral Agents - therapeutic use; Bile Acids and Salts - blood; Biological and medical sciences; Chi-Square Distribution; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Ferritins - blood; Hepatitis C, Chronic - blood; Hepatitis C, Chronic - drug therapy; Human viral diseases; Humans; Infectious diseases; interferon; Interferon-alpha - therapeutic use; Linear Models; liver; Male; Medical sciences; non-response; Pharmacology. Drug treatments; Predictive Value of Tests; Recombinant Proteins; Retrospective Studies; ribavirin; Ribavirin - therapeutic use; Treatment Outcome; Viral diseases; Viral diseases of the digestive system; Viral hepatitis; virus; Prognosis; liver; Cytokine; Ferritin; Hepatic disease; Non response; non-response; Ribavirin; Infection; Virus; Chronic; Treatment; Viral disease; Bile acid; Digestive diseases; Antiviral; Serum; Interferon; Predictive factor; Failure; Viral hepatitis C

Aim: To investigate the relationship between serum levels of ferritin and bile acids (BA) and the response to antiviral treatment in chronic hepatitis C (HCV). Methods: A retrospective study was carried out on 35 control volunteers and 50 patients receiving interferon alpha‐2b alone or plus ribaviri...