Laser treatment of keloids and hypertrophic scars

• Published in: International journal of dermatology Vol. 46; no. 1; pp. 80 - 88
• Main Authors: Bouzari, Navid, Davis, Stephen C., Nouri, Keyvan
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2007; Blackwell Science
• Subjects: Biological and medical sciences; Cicatrix, Hypertrophic - physiopathology; Cicatrix, Hypertrophic - surgery; Dermatology; Humans; Keloid - physiopathology; Keloid - surgery; Laser Therapy; Medical sciences; Skin involvement in other diseases. Miscellaneous. General aspects; Treatment Outcome; Skin disease; Treatment; Cheloid; Dermatology; Scar; Laser; Hypertrophy
• ISSN: 0011-9059; 1365-4632
• DOI: 10.1111/j.1365-4632.2007.03104.x

Background  Lasers have been used in the treatment of hypertrophic scars and keloids for more than 20 years. Different laser systems have been examined; among them pulsed dye lasers are currently considered the laser of choice in these settings. Objectives  The purpose of this study is to review the pertinent literature and provide updated information on different laser therapies available for treatment of keloids and hypertrophic scars. Methods  A Medline literature search was performed for relevant publications. Results  In this review the results of published studies in the treatment and prevention of hypertrophic scars and keloids are presented. Suggested mechanisms of action are reviewed. A review of the optimal laser parameters to modulate treatment outcome will be discussed. Different lasers are effective in not only the treatment but also the prevention of hypertrophic scars and keloids, among them PDL is more promising. Most of the suggested theories are based on the selective photothermolysis in which the light energy emitted from a vascular laser is absorbed by hemoglobin, generating heat and leading to coagulation necrosis, neocollagenesis, collagen fiber heating with dissociation of disulfide bonds and subsequent collagen fiber realignment. Conclusion  The optimal laser is currently 585 nm PDL, although the recent results of Q‐switched 532 nm frequency‐doubled Nd:YAG are promising. Early use of lasers are beneficial, especially in those who are prone to develop these lesions.