Oxidative stress and apoptosis: Impact on cancer therapy

It is well established that some chemotherapeutic agents and radiation therapy generate reactive oxygen species (ROS) in patients during cancer therapy. Free radicals, particularly ROS have been proposed as common mediators for apoptosis. Recent studies have demonstrated that the mode of cell death...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 96; no. 9; pp. 2181 - 2196
Main Author Ozben, Tomris
Format Journal Article
LanguageEnglish
Published Hoboken Elsevier Inc 01.09.2007
Wiley Subscription Services, Inc., A Wiley Company
Wiley
American Pharmaceutical Association
Subjects
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis - drug effects
Apoptosis - physiology
Biological and medical sciences
cancer
cancer chemotherapy
Caspases - metabolism
Cell Death - drug effects
cell lines
Cell Proliferation - drug effects
DNA Damage - drug effects
Enzyme Activation
General pharmacology
Humans
Medical sciences
multidrug resistance
Neoplasms - drug therapy
Neoplasms - pathology
oligonucleotides
oxidation
Oxidative Stress - drug effects
Oxidative Stress - physiology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Reactive Oxygen Species - metabolism
oxidation
multidrug resistance
cancer
oligonucleotides
cell lines
cancer chemotherapy
Oxidative stress
Pharmaceutical technology
Malignant tumor
Metabolism
In vitro
Chemotherapy
Treatment
Cell death
Multiple resistance
Established cell line
Oligonucleotide
Oxidation
Pharmacokinetics
Apoptosis
Cancer
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Summary:It is well established that some chemotherapeutic agents and radiation therapy generate reactive oxygen species (ROS) in patients during cancer therapy. Free radicals, particularly ROS have been proposed as common mediators for apoptosis. Recent studies have demonstrated that the mode of cell death depends on the severity of the oxidative damage. This review will address some of the current paradigms of oxidative stress, and antioxidants on apoptosis, and discuss the potential mechanisms by which oxidants can regulate apoptotic pathways. It will also review new developments in eliminating cancer cells by selectively inducing apoptosis. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2181–2196, 2007
Bibliography:istex:6CB1501DE8D7C39C810E883534A7BF6A719CA25F
ark:/67375/WNG-9QQ8R6QP-S
ArticleID:JPS20874
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.20874