Localized reactive angioendotheliomatosis

• Published in: Clinical and experimental dermatology Vol. 32; no. 1; pp. 45 - 47
• Main Authors: Kirke, S., Angus, B., Kesteven, P. J. L., Calonje, E., Simpson, N.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2007; Blackwell
• Subjects: Antibodies, Anticardiolipin - blood; Aortic Valve Stenosis - complications; Biological and medical sciences; Dermatology; Female; Hemangioendothelioma - etiology; Hemangioendothelioma - pathology; Humans; Medical sciences; Middle Aged; Neoplasms, Vascular Tissue - etiology; Neoplasms, Vascular Tissue - pathology; Protein C Deficiency - complications; Thrombosis - drug therapy; Vascular disorders of the skin; Vascular disease; Angioendotheliomatosis; Angioma; Skin disease; Dermatology; Cardiovascular disease; Malignant tumor; Localized
• ISSN: 0307-6938; 1365-2230
• DOI: 10.1111/j.1365-2230.2006.02254.x

Summary We present a unique case of a woman with multiple painful dermal lesions localized to the left upper quadrant of the body. Histological investigation revealed microvascular thrombosis with capillary‐wall proliferation. Further investigation revealed a very high anticardiolipin IgG titre and a left subclavian stenosis, presumably providing the reduced blood flow and relative hypoxia to allow microthromboses to occur in the presence of a thrombophilic tendency. Similar clinical and histological features have been reported in patients with the antiphospholipid syndrome and cases of reactive angioendotheliomatosis (RAE). This case represents a unique variant of RAE.