Effector memory and late memory T cells accumulate in the blood of CMV‐carrying individuals but not in their cerebrospinal fluid

Cytomegalovirus (CMV)‐carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non‐carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of cen...

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Published inCytometry. Part B, Clinical cytometry Vol. 84B; no. 4; pp. 218 - 221
Main Authors Jongste, Adriaan H. C., Graaf, Marieke T., den Broek, Patricia D. M., Kraan, Jaco, Sillevis Smitt, Peter A. E., Gratama, Jan W.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.07.2013
Subjects
Adult
Aged
Aged, 80 and over
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Central Nervous System - immunology
Central Nervous System - virology
cerebrospinal fluid
Cerebrospinal Fluid - immunology
Cerebrospinal Fluid - metabolism
Cerebrospinal Fluid - virology
Cytomegalovirus
Cytomegalovirus - metabolism
Cytomegalovirus - pathogenicity
Cytomegalovirus Infections - blood
Cytomegalovirus Infections - virology
Female
flow cytometry
Humans
Immunologic Memory
immunology
Leukocyte Common Antigens - blood
Leukocyte Common Antigens - immunology
Lymphocyte Count
Male
Middle Aged
T cell
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Summary:Cytomegalovirus (CMV)‐carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non‐carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV‐carrying individuals, we characterized CD4+ and CD8+ T‐cell subsets in CSF and blood of both groups. Effector memory and late memory T cells were only rarely seen in CSF, which was similar in CMV carriers and non‐carriers. In conclusion, there was no demonstrable difference in the numbers of CSF effector memory and late memory T cells between CMV seronegative and CMV seropositive individuals. © 2013 International Clinical Cytometry Society
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ISSN:1552-4949
1552-4957
DOI:10.1002/cyto.b.21073