Characterization of the dental lymphatic system and identification of cells immunopositive to specific lymphatic markers
The lymphatic system is important for immune barrier function and for tissue fluid balance. During inflammation, lymphangiogenesis takes place to enhance the transport of filtered fluid, proteins, and immune cells. Dental tissue is frequently exposed to inflammatory insults, but the lymphatic system...
Saved in:
Published in | European journal of oral sciences Vol. 117; no. 1; pp. 34 - 42 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.2009
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The lymphatic system is important for immune barrier function and for tissue fluid balance. During inflammation, lymphangiogenesis takes place to enhance the transport of filtered fluid, proteins, and immune cells. Dental tissue is frequently exposed to inflammatory insults, but the lymphatic system and its responses to injury have not been investigated in detail using specific lymphatic markers. We aimed to study this system and to establish whether lymphangiogenesis takes place during wound healing. Immunostaining of the lymphatic endothelial hyaluronan receptor‐1 (LYVE‐1) and vascular endothelial growth factor receptor‐3 (VEGFR‐3) demonstrated initial lymphatics in the coronal molar pulp, whereas in incisors the initial lymphatics were found only in the apical part. In molars, lymphatic vessels exit the pulp through the apex and lateral canals. In interdental bone, transverse lymphatics were found, raising the possibility that an infection can be spread from the periodontal ligament to a neighbouring tooth. LYVE‐1+ and VEGFR‐3+ immune cells were found in both molar and incisor pulps, and phenotyping of the cells showed that they are of a monocytic lineage. In inflamed pulp these cells were not observed. Macrophages are suggested to contribute directly to the formation of lymphatic vessels after pulp exposure. |
---|---|
Bibliography: | istex:6D3C01F7FC29D03212D77CD264B260F9A0463EEF ArticleID:EOS592 ark:/67375/WNG-CW702ZWM-F ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0909-8836 1600-0722 |
DOI: | 10.1111/j.1600-0722.2008.00592.x |