Study of compliance with a new, targeted antenatal D immunization prevention programme in Denmark

• Published in: Vox sanguinis Vol. 103; no. 2; pp. 145 - 149
• Main Authors: Damkjær, M. B., Perslev, A., Clausen, F. B., Dziegiel, M. H., Jørgensen, F. S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2012; S. Karger AG
• Subjects: Adult; antenatal prophylaxis; cell-free fetal DNA; Compliance; Denmark; Disease prevention; Female; Guideline Adherence; Humans; Immunization; Immunoglobulins; Maternal & child health; Practice Guidelines as Topic; Pregnancy; Pregnancy Complications, Hematologic - prevention & control; Rh Isoimmunization - prevention & control; RHD genotyping; Denmark
• ISSN: 0042-9007; 1423-0410
• DOI: 10.1111/j.1423-0410.2012.01602.x

Background and Objectives  A targeted routine antenatal anti‐D prophylaxis programme was implemented in Denmark where anti‐D immunoglobulin is given based on the result from noninvasive antenatal screening for fetal RHD. Our objective was to evaluate compliance with this new programme right after its initiation. Materials and Methods  We examined the treatment outcome of 239 D‐negative pregnant women who gave birth at our hospital between June and September 2010. Results  The majority of these women (90%) underwent antenatal RHD screening, 86% of the women who were recommended antenatal prophylaxis received anti‐D, and 99% of the women who delivered RhD‐positive infants received postnatal anti‐D. Conclusion  These compliance results are acceptable as they were obtained only a few months after the initiation of the new prophylaxis regime. However, suggestions to further improve compliance are presented.