Comparison between dexmedetomidine and fentanyl on intubation conditions during awake fiberoptic bronchoscopy: A randomized double-blind prospective study

• Published in: Journal of anaesthesiology, clinical pharmacology Vol. 31; no. 2; pp. 212 - 216
• Main Authors: Mondal, Sudeshna, Ghosh, Sarmila, Bhattacharya, Susmita, Choudhury, Brojen, Mallick, Suchismita, Prasad, Anu
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.04.2015; Medknow Publications & Media Pvt Ltd
• Subjects: Analysis; Anoxemia; Bronchoscopy; Care and treatment; Diagnosis; Fiber optic equipment; Health aspects; Hemodynamics; Original; dexmedetomidine hydrochloride; fentanyl citrate; Awake intubation
• ISSN: 0970-9185; 2231-2730
• DOI: 10.4103/0970-9185.155151

Various drugs are used for providing favorable intubation conditions during awake fiberoptic intubation (AFOI). However, most of them cause respiratory depression and airway obstruction leading to hypoxemia. The aim of this study was to compare intubation conditions, and incidence of desaturation between dexmedetomidine and fentanyl group during AFOI. This randomized double-blind prospective study was conducted on a total of 60 patients scheduled for elective laparotomies who were randomly allocated into two groups: Group A received dexmedetomidine 1 mcg/kg and Group B received fentanyl 2 mcg/kg over 10 min. Patients in both groups received glycopyrrolate 0.2 mg intravenous, nebulization with 2% lidocaine 4 ml over 20 min and 10% lidocaine spray before undergoing AFOI. Adequacy of intubation condition was evaluated by cough score and post-intubation score. Incidence of desaturation, hemodynamic changes and sedation using Ramsay sedation scale (RSS) were noted and compared between two groups. Cough Score (1-4), post-intubation Score (1-3) and RSS (1-6) were significantly favorable (P < 0.0001) along with minimum hemodynamic responses to intubation (P < 0.05) and less oxygen desaturation (P < 0.0001) in Group A than Group B. Dexmedetomidine is more effective than fentanyl in producing better intubation conditions, sedation along with hemodynamic stability and less desaturation during AFOI.