Multicompartmental Mathematical Model of SARS-CoV-2 Distribution in Human Organs and Their Treatment

Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease requires further research on the pathogenesis of this disease. Based on the analysis of published data and original exp...

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Published inMathematics (Basel) Vol. 10; no. 11; p. 1925
Main Authors Afonyushkin, Vasiliy N, Akberdin, Ilya R, Kozlova, Yulia N, Schukin, Ivan A, Mironova, Tatyana E, Bobikova, Anna S, Cherepushkina, Viktoriya S, Donchenko, Nikolaj A, Poletaeva, Yulia E, Kolpakov, Fedor A
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.06.2022
Subjects
Aerosols
Coronaviruses
COVID-19
Esophagus
Food science
Gastrointestinal system
Human tissues
immunology
Infections
Intestine
intestines
Lungs
Mathematical models
nasopharynx
Ordinary differential equations
Organs
Pandemics
Pathogenesis
Sanitation
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Viral diseases
Viruses
Russia
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Summary:Patients with COVID-19 can develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease requires further research on the pathogenesis of this disease. Based on the analysis of published data and original experiments on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs, and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of the viral particles can transport to the esophagus from the nasopharynx. The viral particles entering the gastrointestinal tract will obviously be accompanied by the infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional to their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from the nasopharynx and intestines to the lungs. The model simulations also suppose that sanitation of the nasopharynx mucosa at the initial stage of the infectious process has prospects for the use in medical practice.
ISSN:2227-7390
2227-7390
DOI:10.3390/math10111925