Molecular Mechanisms Underlying PGF2α-induced Hypertrophy of Vascular Smooth Muscle Cells

The present review focuses primarily on the studies we made in recent years to improve the understanding of the molecular mechanisms of PGF2α-induced hypertrophy of Vascular Smooth Muscle Cells (VSMC). In this review, we will summarize the recent findings in the context of the PGF2α signaling pathwa...

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Published inYAKUGAKU ZASSHI Vol. 130; no. 2; pp. 211 - 214
Main Authors FAN, Chunyuan, KATSUYAMA, Masato, WEI, Haiyan, XIA, Qingjie, LIU, Wentao, YABE-NISHIMURA, Chihiro
Format Journal Article
LanguageEnglish
Published The Pharmaceutical Society of Japan 01.02.2010
Subjects
hypertrophy
NOX1
PGF2α
Vascular Smooth Muscle Cells (VSMC)
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Summary:The present review focuses primarily on the studies we made in recent years to improve the understanding of the molecular mechanisms of PGF2α-induced hypertrophy of Vascular Smooth Muscle Cells (VSMC). In this review, we will summarize the recent findings in the context of the PGF2α signaling pathway in three parts: PGF2α binding to its receptor, transactivation of EGF receptor, two independent signaling transduction pathways increasing the expression of NOX1 gene.
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi.130.211