Repellent activity of monoterpenoid esters with neurotransmitter amino acids against yellow fever mosquito, Aedes aegypti

• Published in: Open Chemistry Vol. 16; no. 1; pp. 95 - 98
• Main Authors: Nesterkina, Mariia, Bernier, Ulrich R., Tabanca, Nurhayat, Kravchenko, Iryna
• Format: Journal Article
• Language: English
• Published: De Gruyter 09.03.2018
• Subjects: GABA; glycine; monoterpenoids; mosquito; repellents
• ISSN: 2391-5420; 2391-5420
• DOI: 10.1515/chem-2018-0015

Repellent activity of monoterpenoid esters ( ) with neurotransmitter amino acids (GABA and glycine) was investigated against by using a “cloth-patch” assay and compared to reference standard -diethyl-3-methylbenzamide (DEET). Monoterpenoid esters showed repellent activity with minimum effective dosages (MED) in the range of 0.031-0.469 mg/cm . The carvacrol ester of GABA ( , MED of 0.031 ± 0.008 mg/cm ) exhibited the highest repellency of six monoterpenoid esters tested in comparison to the standard repellent DEET (MED of 0.009 ± 0.002 mg/cm ); however, the repellent activity of carvacrol-glycine ester ( ) decreased 4-fold compared to the carvacrol-GABA derivative ( ). The repellent activities of menthol GABA ( , MED= 0.375 ± 0.000 mg/cm ) and glycine ester ( , MED=0.312 ± 0.063 mg/cm ) were similar The guaiacol-glycine ester ( ) was 3.75-fold more efficacious than the guaiacol ester of GABA ( ). In the present study, we report repellent efficacy of prolonged exposure to GABA and glycine esters of menthol, carvacrol, guaiacol ( ) as compared to the repellent activities of their monoterpene moieties alone.