Growth of vascularized composite mandibular allografts in young rabbits

Forty-one hemimandible allografts were transplanted in young rabbits immunosuppressed with cyclosporine. The majority of the grafts demonstrated normal wound healing, and growth of hair, bone, and teeth. The mandibular body and the premolars showed significant growth in length. The allografted mandi...

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Bibliographic Details
Published inAnnals of plastic surgery Vol. 26; no. 2; p. 140
Main Authors Randzio, J, Kniha, H, Gold, M E, Chang, T T, Su, L D, Park, H H, Cho, J S, Booth, K, Furnas, D W
Format Journal Article
LanguageEnglish
Published United States 01.02.1991
Subjects
Animals
Cyclosporins - adverse effects
Cyclosporins - therapeutic use
Female
Graft Rejection
Mandible - diagnostic imaging
Mandible - transplantation
Muscles - transplantation
Postoperative Complications
Rabbits
Radiography
Radionuclide Imaging
Skin Transplantation
Transplantation, Autologous
Transplantation, Homologous
Wound Healing
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Summary:Forty-one hemimandible allografts were transplanted in young rabbits immunosuppressed with cyclosporine. The majority of the grafts demonstrated normal wound healing, and growth of hair, bone, and teeth. The mandibular body and the premolars showed significant growth in length. The allografted mandibles functioned sufficiently that the rabbits took oral nourishment soon after surgery. Long-term survival was limited by a toxic "wasting syndrome" specific for rabbits under treatment with cyclosporine.
ISSN:0148-7043
DOI:10.1097/00000637-199102000-00006