Postoperative Nutritional Effects of Early Enteral Feeding Compared with Total Parental Nutrition in Pancreaticoduodectomy Patients: A Prosepective, Randomized Study

• Published in: Journal of Korean medical science Vol. 27; no. 3; pp. 261 - 267
• Main Authors: Park, Joon Seong, Chung, Hye-Kyung, Hwang, Ho Kyoung, Kim, Jae Keun, Yoon, Dong Sup
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.03.2012; 대한의학회
• Subjects: Aged; Carcinoma, Pancreatic Ductal - physiopathology; Carcinoma, Pancreatic Ductal - surgery; Carcinoma, Pancreatic Ductal - therapy; Digestive System - physiopathology; Enteral Nutrition - adverse effects; Female; Humans; Male; Middle Aged; Nutritional Status; Original; Pancreatic Neoplasms - physiopathology; Pancreatic Neoplasms - surgery; Pancreatic Neoplasms - therapy; Pancreaticoduodenectomy - adverse effects; Parenteral Nutrition, Total; Postoperative Care - methods; Postoperative Period; Prospective Studies; Time Factors; Treatment Outcome; Weight Gain; Weight Loss; 의학일반; TPN; Pancreaticoduodenectomy; Nutrition; Early Enetral Feeding
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2012.27.3.261

The benefits of early enteral feeding (EEN) have been demonstrated in gastrointestinal surgery. But, the impact of EEN has not been elucidated yet. We assessed the postoperative nutritional status of patients who had undergone pancreaticoduodenectomy (PD) according to the postoperative nutritional method and compared the clinical outcomes of two methods. A prospective randomized trial was undertaken following PD. Patients were randomly divided into two groups; the EEN group received the postoperative enteral feed and the control group received the postoperative total parenteral nutrition (TPN) management. Thirty-eight patients were included in our analyses. The first day of bowel movement and time to take a normal soft diet was significantly shorter in EEN group than in TPN group. Prealbumin and transferrin were significantly reduced on post-operative day (POD) 7 and were slowly recovered until POD 90 in the TPN group than in the EEN group. EEN group rapidly recovered weight after POD 21 whereas it was gradually decreased in TPN group until POD 90. EEN after PD is associated with preservation of weight compared with TPN and impact on recovery of digestive function after PD.