Recent advances towards the fabrication and biomedical applications of responsive polymeric assemblies and nanoparticle hybrid superstructures

Responsive polymeric assemblies and hybrid superstructures fabricated from stimuli-sensitive polymers and inorganic nanoparticles (NPs) have been the subject of extensive investigations during the past few decades due to their distinct advantages such as an improved water solubility, stimuli-respons...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 44; no. 9; pp. 394 - 3922
Main Authors Hu, Xianglong, Liu, Shiyong
Format Journal Article
LanguageEnglish
Published England 07.03.2015
Subjects
Addition polymerization
Animals
Assemblies
Drug delivery systems
Drugs
Humans
Imaging
Nanomedicine
Nanoparticles - chemistry
Nanostructure
Polymers
Polymers - chemistry
Superstructures
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Summary:Responsive polymeric assemblies and hybrid superstructures fabricated from stimuli-sensitive polymers and inorganic nanoparticles (NPs) have been the subject of extensive investigations during the past few decades due to their distinct advantages such as an improved water solubility, stimuli-responsiveness, excellent biocompatibility, and facile introduction of functional units. In addition, the chemical compositions of polymeric assemblies and corresponding hybrid superstructures can be modulated via the initial synthetic design to target desired functions, fabricate smart nanostructures, and explore morphology-dependent functional optimization. Promising applications in the field of imaging, sensing, drug/gene delivery, diagnostics, and nanoreactors are being extensively investigated. This perspective article focuses on recent developments, microstructural control, and biomedical applications of stimuli-responsive polymeric assemblies as well as responsive hybrid superstructures fabricated from responsive polymers and inorganic NP building blocks (gold NPs and magnetic iron oxide NPs), and highlights their current status and future developments with selected literature reports. We highlight recent developments, microstructural control, and biomedical applications of stimuli-responsive polymeric assemblies and responsive hybrid superstructures.
Bibliography:Xianglong Hu was born in Anhui Province, China, in 1985. He received his B.S. degree in 2007 and M.S. degree in 2010 from Anhui Normal University, majoring in chemistry and polymer chemistry, respectively. He then entered the Department of Polymer Science and Engineering, University of Science and Technology of China, and obtained his Ph.D. degree in 2014 under the supervision of Prof. Shiyong Liu. Now, he is working at South China Normal University as a lecturer. His current research interests focus on polymer self-assembly and stimuli-responsive polymeric materials and hybrid materials for therapeutics, imaging, and anticancer/antibacterial applications.
Shiyong Liu has been a professor of Polymer Science and Engineering at the University of Science and Technology of China since 2004. He is a recipient of 100 Talents Program (CAS, 2004), Distinguished Young Scholars Award (NSFC, 2004), and Cheung Kong Professor Award (Ministry of Education of China, 2009). He has served on the Editorial Advisory Board for Macromolecules (ACS, 2008-2010), Macromolecular Rapid Communications, Macromolecular Chemistry and Physics, Biomacromolecules, and Polymer Chemistry. He has published over 200 peer-reviewed journal papers with a total citation of more than 8000 and an H-index of 51. His current research interests include the design and synthesis of functional polymeric materials, colloids, and stimuli-responsive polymeric assemblies with controlled properties for application in imaging, sensing, diagnostics, and nanomedicine.
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ISSN:1477-9226
1477-9234
1477-9234
DOI:10.1039/c4dt03609c