Nifedipine-induced gingival hyperplasia

Gingival hyperplasia, a condition characterized by increased amounts of gingival connective tissue, has most commonly been observed in patients receiving phenytoin, but has also been noted in patients receiving cyclosporine and, as in this case report, nifedipine. Patients receiving nifedipine shoul...

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Bibliographic Details
Published inDrug intelligence & clinical pharmacy Vol. 20; no. 7-8; p. 602
Main Authors Shaftic, A A, Widdup, L L, Abate, M A, Jacknowitz, A I
Format Journal Article
LanguageEnglish
Published United States 01.07.1986
Subjects
Gingival Hyperplasia - chemically induced
Humans
Male
Middle Aged
Nifedipine - adverse effects
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Summary:Gingival hyperplasia, a condition characterized by increased amounts of gingival connective tissue, has most commonly been observed in patients receiving phenytoin, but has also been noted in patients receiving cyclosporine and, as in this case report, nifedipine. Patients receiving nifedipine should be advised to practice good oral hygiene to lessen the possibility of hyperplasia occurring. If gingival hyperplasia develops in a patient taking nifedipine, the drug should be suspected as being responsible and discontinued. Limited data suggest verapamil can be substituted for nifedipine in these patients with improvement of the hyperplasia.
ISSN:0012-6578
DOI:10.1177/106002808602000724