Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease

• Published in: World journal of gastroenterology : WJG Vol. 21; no. 1; pp. 301 - 310
• Main Authors: Maciejewska, Dominika, Drozd, Arleta, Ossowski, Piotr, Ryterska, Karina, Jamioł-Milc, Dominika, Banaszczak, Marcin, Raszeja-Wyszomirska, Joanna, Kaczorowska, Małgorzata, Sabinicz, Anna, Stachowska, Ewa
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 07.01.2015
• Subjects: acids;Bioch; Adult; Biomarkers - blood; Blood Glucose - metabolism; Dietary Fats - administration & dosage; Dietary Fats - blood; disease;Fatty; Docosahexaenoic Acids - administration & dosage; Docosahexaenoic Acids - blood; Eicosapentaenoic Acid - administration & dosage; Eicosapentaenoic Acid - blood; European Continental Ancestry Group; fatty; Fatty Acids - administration & dosage; Fatty Acids - blood; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Monounsaturated - blood; Fatty Acids, Unsaturated - administration & dosage; Fatty Acids, Unsaturated - blood; Female; Humans; liver; Male; Middle Aged; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - diet therapy; Non-alcoholic Fatty Liver Disease - ethnology; Nonalcoholic; Observational Study; Poland - epidemiology; Prospective Studies; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome; Weight Loss; Young Adult; Gas chromatography; Biochemical parameters; Diet; n-3 Family; n-6 Family; Nonalcoholic fatty liver disease; Sterol regulatory element binding proteins 1c; Fatty acids
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v21.i1.301

AIM: To investigate whether liver steatosis reduction due to a six-month dietary intervention results in significant changes in the concentrations of fatty acids.METHODS: A group of 35 Caucasian individuals diagnosed with different levels of steatosis were prospectively enrolled in the present study.Analysis of the fatty acid profiles was performed according to changes in liver steatosis(liver steatosis reduction by one or two degrees) after a six-month dietary intervention.The diet helped reduce body mass in obese and overweight patients,and stabilize both glycemia and dyslipidemia.Fatty acids were extracted according to the Folch method and analyzed by gas chromatography.RESULTS: This study showed significant changes in fatty acid profiles in patients who had reduced liver steatosis by one as well as two degrees.A reduction in liver steatosis by one degree caused a significant increase in the level of the n-3 family: eicosapentaenoic acid(P < 0.055),docosapentaenoic acid-C 22:5(P < 0.05) and docosahexaenoic acid(P < 0.05).A reduction in liver steatosis by two degrees caused a significant decrease in serum palmitoleic acid-C 16:1(P < 0.05).CONCLUSION: Liver steatosis reduction is associated with changes in fatty acid profiles,and these changes may reflect an alteration in fatty acid synthesis and metabolism.These findings may help better understand regression of nonalcoholic fatty liver disease.