Oral squamous cell carcinoma in human immunodeficiency virus positive patients: clinicopathological audit

• Published in: Journal of laryngology and otology Vol. 126; no. 3; pp. 276 - 278
• Main Authors: Butt, F M A, Chindia, M L, Rana, F
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.03.2012
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; Africa; Age; Age of Onset; AIDS; Alcohol; Biological and medical sciences; Cancer; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - pathology; Classification; Disease; Drug therapy; Female; Females; highly active antiretroviral therapy; HIV; HIV Infections - epidemiology; HIV Long-Term Survivors - statistics & numerical data; Human immunodeficiency virus; Human viral diseases; Humans; Immune system; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infection; Infections; Infectious diseases; Kaposis sarcoma; Life span; Male; Malignancy; Medical Audit; Medical sciences; Metastasis; Mouth Neoplasms - epidemiology; Mouth Neoplasms - pathology; Neoplasm Staging; oral squamous cell carcinoma; Otorhinolaryngology. Stomatology; Patients; Prospective Studies; Risk Factors; Tobacco; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viruses; Young Adult; Africa; United States > US; Carcinoma, Squamous Cell; Human Immunodeficiency Virus; Epidemiology; Oral Cavity; Human; Immunopathology; Carcinoma; Stomatology; Squamous Cell; Retroviridae; AIDS; ENT; Malignant tumor; Oral squamous cell carcinoma; Immune deficiency; Lentivirus; Infection; Virus; Audit; Oral cavity; Viral disease; Oral cavity disease; Human immunodeficiency virus; Cell; Cancer
• ISSN: 0022-2151; 1748-5460
• DOI: 10.1017/S0022215111002647

Most human immunodeficiency virus positive patients now have a longer life expectancy, with the advent of highly active antiretroviral therapy. However, they are now at increased risk of developing a malignancy during their lives. To investigate the age at which oral squamous cell carcinoma presents in patients infected with human immunodeficiency virus. Prospective, clinicohistopathological audit of patients infected with human immunodeficiency virus. Of 200 human immunodeficiency virus positive patients, 16 (8 per cent) presented with oral squamous cell carcinoma (nine women and seven men; age range 18-43 years, mean age 31.7 years). The majority of patients (62.5 per cent) had stage III and IV disease (tumour-node-metastasis staging). There was a predilection for poorly differentiated oral squamous cell carcinoma (using Broder's histopathological classification). Oral squamous cell carcinoma associated with human immunodeficiency virus infection appears to present at a relatively young age.