The Synthesis of Biphasic Metabolites of Carfentanil

Carfentanil is an ultra-potent synthetic opioid. The Russian police force used both carfentanil and remifentanil to resolve a hostage incident in Moscow. This reported use sparked an interest in the pharmacology and toxicology of carfentanil in the human body, and data on its metabolites were later...

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 28; no. 22; p. 7625
Main Authors Wang, Junchang, Hu, Jianwen, Liao, Pingyong, Xue, Shang, He, Shan, Chen, Ruijia, Zhao, Xuejun, Liu, Wenbin
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2023
Subjects
Alfentanil
Analgesics
carbohydrate
carfentanil
Chromatography
Fentanyl
glycoconjugates
metabolism
Metabolites
Narcotics
NMR
Nuclear magnetic resonance
Raw materials
Remifentanil
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Summary:Carfentanil is an ultra-potent synthetic opioid. The Russian police force used both carfentanil and remifentanil to resolve a hostage incident in Moscow. This reported use sparked an interest in the pharmacology and toxicology of carfentanil in the human body, and data on its metabolites were later published. However, there have been few studies on the synthesis of carfentanil metabolites, and biological extraction has also put forward large uncertainty in subsequent studies. The aim of the present study is to investigate the synthesis of biphasic metabolites that are unique to carfentanil. The purpose was to produce corresponding metabolites conveniently, quickly, and at low cost that can be used for comparison with published structures and to confirm the administration of carfentanil.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28227625