Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice

• Published in: Food & function Vol. 5; no. 7; pp. 1579 - 1586
• Main Authors: Seo, Kwon-Il, Lee, Jin, Choi, Ra-Yeong, Lee, Hae-In, Lee, Ju-Hye, Jeong, Yong-Ki, Kim, Myung-Joo, Lee, Mi-Kyung
• Format: Journal Article
• Language: English
• Published: England 2014
• Subjects: Acetic Acid - pharmacology; Acetyl-CoA Carboxylase - metabolism; Adipose Tissue - drug effects; Adipose Tissue - metabolism; AMP-Activated Protein Kinases - metabolism; Animals; Beverages - analysis; Blood Glucose - metabolism; Body Weight - drug effects; Cholesterol - blood; Diet, High-Fat - adverse effects; Fatty Acids, Nonesterified - blood; Food Handling; Homeostasis - drug effects; Insulin - blood; Insulin Resistance; Lipid Metabolism - drug effects; Liver - drug effects; Liver - metabolism; Lycopersicon esculentum; Lycopersicon esculentum - chemistry; Male; Mice, Inbred C57BL; Mice, Obese; Obesity - diet therapy; Obesity - etiology; PPAR alpha - metabolism; Triglycerides - blood
• ISSN: 2042-6496; 2042-650X
• DOI: 10.1039/c4fo00135d

This study investigated the mechanism of processed tomato vinegar beverage (TVB)-mediated anti-obesity and anti-insulin resistance effects in high-fat diet (HF)-induced obese mice. Oral administration of TVB (14 mL kg −1 body weight) to HF-fed mice for 6 weeks effectively reduced the body and visceral fat weight and significantly lowered plasma free fatty acid, triglyceride and hepatic triglyceride levels. TVB significantly increased fecal triglyceride excretion, both phosphorylated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) and peroxisome proliferator-activated receptor (PPAR)α protein levels in the liver, which were associated with increased fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice. TVB improved glucose tolerance, hyperinsulinemia and HOMA-IR levels in the HF + TVB group compared to the HF group. Additionally, TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, which enhanced glucose metabolism in obese mice. These results suggest that TVB prevents visceral obesity and insulin resistance via AMPK/PPARα-mediated fatty acid and glucose oxidation. This study investigated the mechanism of processed tomato vinegar beverage (TVB)-mediated anti-obesity and anti-insulin resistance effects in high-fat diet (HF)-induced obese mice.