Intestinal T-cell lymphomas:A retrospective analysis of 68 cases in China

• Published in: World journal of gastroenterology : WJG Vol. 20; no. 1; pp. 296 - 302
• Main Authors: Sun, Zhi-Huan, Zhou, Hai-Meng, Song, Guo-Xin, Zhou, Zhong-Xiao, Bai, Liang
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 07.01.2014
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomarkers, Tumor - analysis; Brief; CD56 Antigen - analysis; Chemotherapy, Adjuvant; China; Colonoscopy; Diagnostic Errors; Digestive System Surgical Procedures - adverse effects; Enteropathy-associated; Female; Humans; Intestinal Neoplasms - immunology; Intestinal Neoplasms - mortality; Intestinal Neoplasms - pathology; Intestinal Neoplasms - therapy; Kaplan-Meier Estimate; lymphoma; Lymphoma, Extranodal NK-T-Cell - immunology; Lymphoma, Extranodal NK-T-Cell - mortality; Lymphoma, Extranodal NK-T-Cell - pathology; Lymphoma, Extranodal NK-T-Cell - therapy; Lymphoma, T-Cell - immunology; Lymphoma, T-Cell - mortality; Lymphoma, T-Cell - pathology; Lymphoma, T-Cell - therapy; Male; Middle Aged; NK/T-cell; Postoperative Complications - surgery; Predictive Value of Tests; Reoperation; T-cell; Time Factors; Treatment Outcome; Young Adult; Enteropathy-associated T-cell lymphoma; NK/T-cell lymphoma; Enterostomy; Intestinal T-cell lymphoma; Intestinal perforation
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v20.i1.296

AIM:To investigate the clinical features,diagnosis,treatment and prognosis of intestinal T-cell lymphomas(ITCL)by retrospective analysis.METHODS:Sixty-eight patients who were diagnosed with ITCL in case reports in the Chinese literature were compiled and reviewed.Age,gender,CD56 expression,surgical management,multifocal nature,perforation and cyclophosphamide chemotherapy were analyzed as the prognostic factors.The Kaplan-Meier method was adopted for the univariate analysis and the cumulative survival curve analysis.RESULTS:The male-to-female ratio was 1.52 to 1.The median age was 41.7 years.Twenty-seven patients had symptoms of abdominal pain or diarrhea.Thirty-six of60 patients with temperature records had high fevers at the onset of the illness.Twenty-six of 34 patients who underwent fiberoptic colonoscopy were misdiagnosed with Crohn’s disease,intestinal tuberculosis or cancer.Sixty-one patients underwent surgery.Twelve of 61 surgical patients required a second operation for anastomotic leakage or secondary perforation.The sites of lesion involvement were the jejunum(8.82%),ileum(29.41%),ileum and colon(4.41%),colon(55.88%)and appendix(1.47%).The median cumulative survival rate was 3 mo(3.00±0.48).CONCLUSION:Efforts should be made to correctly diagnose ITCL and select the proper operative approach that may reduce serious complications and create opportunities for further treatment.