Glioblastoma: approach to treat elderly patients

Treating elderly cancer patients is a challenge for oncologists, especially considering the several therapeutic modalities in glioblastoma. Extensive tumor resection offers the best chance of local control. Adequate radiotherapy should always be given to elderly patients if they have undergone gross...

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Bibliographic Details
Published inEinstein (São Paulo, Brazil) Vol. 10; no. 4; pp. 512 - 518
Main Authors Pontes, Luciola de Barros, Karnakis, Theodora, Malheiros, Suzana Maria Fleury, Weltman, Eduardo, Brandt, Reynaldo André, Guendelmann, Rafael Aliosha Kaliks
Format Journal Article
LanguageEnglish
Published Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein 01.12.2012
Subjects
Age Factors
Aged
antineoplásicos alquilantes
avaliação geriátrica
DNA Methylation
Geriatric Assessment
glioblastoma
Glioblastoma - genetics
Glioblastoma - therapy
Humans
idoso
MEDICINE, GENERAL & INTERNAL
Promoter Regions, Genetic
radioterapia
Treatment Outcome
Geriatric assessment
Antineoplásicos alquilantes
Idoso
Glioblastoma
Aged
Radiotherapy
Avaliação geriátrica
Radioterapia
Antineoplasic agents, alkylating
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Summary:Treating elderly cancer patients is a challenge for oncologists, especially considering the several therapeutic modalities in glioblastoma. Extensive tumor resection offers the best chance of local control. Adequate radiotherapy should always be given to elderly patients if they have undergone gross total resection and have maintained a good performance status. Rather than being ruled out, chemotherapy should be considered, and temozolomide is the chosen drug. A comprehensive geriatric assessment is a valuable tool to help guiding treatment decisions in elderly patients with glioblastoma.
ISSN:1679-4508
2317-6385
2317-6385
1679-4508
DOI:10.1590/S1679-45082012000400021