A biomemory chip composed of a myoglobin/CNT heterolayer fabricated by the protein-adsorption-precipitation-crosslinking (PAPC) technique

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 136; pp. 853 - 858
• Main Authors: Yoon, Jinho, Chung, Yong-Ho, Lee, Taek, Kim, Jae Hyun, Kim, Jungbae, Choi, Jeong-Woo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2015
• Subjects: Adsorption; Biomaterials; Biomemory chip; Carbon nanotubes; Chip formation; Devices; Durability; Electrochemical signal enhancement; Electrochemical signal stability; High density; Morphology; Myoglobin; Myoglobin - chemistry; Nanotubes, Carbon; Protein-adsorption-precipitation-crosslinking (PAPC) technique; Stability; Surface Properties; Carbon nanotubes; Electrochemical signal stability; Protein-adsorption-precipitation-crosslinking (PAPC) technique; Electrochemical signal enhancement; Biomemory chip
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2015.10.030

A Biomemory chip composed of myoglobin/carbon nanotubes by PAPC technique for electrochemical signal enhancement, long-term stability and advanced memory function. [Display omitted] •We fabricate a biomemory chip composed of myoglobin and CNT.•Myoglobin and CNT are effectively combined by PAPC technique.•Fabricated biomemory chip by PAPC technique shows electrochemical signal enhancement and long-term stability.•Fabricated biomemory chip by PAPC technique also shows advanced memory function compared to samples fabricated without PAPC technique. In this study, a biomemory chip consisting of a myoglobin/carbon nanotube (CNT) heterolayer is fabricated via the protein-adsorption-precipitation-crosslinking (PAPC) technique for electrochemical signal enhancement, long-term stability, and improved memory function. The PAPC technique is used to fabricate a myoglobin/CNT heterolayer with a CNT core and a high-density myoglobin-shell structure to achieve efficient heterolayer formation and improved performance of the heterolayer. The fabricated myoglobin/CNT heterolayer is immobilized onto a Au substrate through a chemical linker. The surface morphology of the deposited heterolayer is investigated via transmission electron microscopy and atomic force microscopy. The redox properties of the myoglobin/CNT heterolayer are investigated by cyclic voltammetry, and the memory function of the heterolayer, including the “write step” and “erase step,” is measured by chronoamperometry. Compared with the myoglobin monolayer without CNT, the myoglobin/CNT heterolayer fabricated by the PAPC technique exhibits greater electrochemical signal enhancement, long-term stability at room temperature, and improved memory function. The results suggest that the proposed myoglobin/CNT heterolayer produced via the PAPC technique can be applied as a platform for bioelectronic devices to achieve improved signal intensity and durability.