Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis?

• Published in: Journal of laryngology and otology Vol. 125; no. 11; pp. 1121 - 1124
• Main Authors: Iriz, A, Eryilmaz, A, Gocer, C, Acar, A, Boynuegri, S, Dursun, E
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.11.2011
• Subjects: Adult; Atherosclerosis; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Biopsy; Chronic Disease; Ear diseases; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Ear, Middle - microbiology; Ear, Middle - pathology; Eardrum; Etiology; Female; Gastroesophageal reflux; Gastroesophageal Reflux - epidemiology; Hearing loss; Helicobacter Infections - complications; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - isolation & purification; Helicobacter pylori - pathogenicity; Human bacterial diseases; Humans; Infections; Infectious diseases; Male; Mastoid - surgery; Medical sciences; Mucosa; Mucous Membrane; Myringoplasty; Non tumoral diseases; Otitis media; Otitis Media - microbiology; Otitis Media - pathology; Otitis Media - surgery; Otorhinolaryngology. Stomatology; Pathology; Patients; Prospective Studies; Radicals; Sclerosis; Statistical analysis; Surgery; Tympanic Membrane - microbiology; Tympanic Membrane - pathology; Tympanic Membrane - surgery; Tympanoplasty; United States > US; H Pylori; Tympanosclerosis; Chronic inflammation; Tympanic Membrane; Ear, Middle; Tympanum; Spirillales; Middle ear disease; Spirillaceae; Inflammation; ENT; Middle; Chronic; Helicobacter pylori; Ear; Bacteria; ENT disease
• ISSN: 0022-2151; 1748-5460
• DOI: 10.1017/S0022215111002301

The aetiology of tympanosclerosis is not yet clear. This prospective, controlled, clinical study investigated the relationship between Helicobacter pylori and tympanosclerosis aetiology. The study included 14 patients with tympanosclerosis and 26 with other forms of chronic otitis media. All patients underwent surgery for chronic otitis media. Mucosal biopsies were taken, and examined for H pylori using the Campylobacter-Like Organism (CLO) test. Tympanoplasty was performed in 29 patients (72.5 per cent), radical mastoidectomy in eight (20 per cent) and myringoplasty in three (7.5 per cent). The presence of H pylori was tested in all tympanosclerosis biopsies, but in only 26.9 per cent of biopsies from other forms of chronic otitis media. A statistically significant difference in H pylori presence was found (p ≤ 0.01). This study represents a preliminary investigation of the association between H pylori and tympanosclerosis development.