Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report

Abstract Introduction: Diffuse lung cysts occur owing to several diseases; however, diffuse cystic lung metastases are very rare in the case of lung cancer. We report a rare case of diffuse cystic lung metastases from lung adenocarcinoma and reviewed previously reported cases of cystic lung metastas...

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Published inCase reports in oncology Vol. 16; no. 1; pp. 1409 - 1414
Main Authors Matsukida, Akira, Ogawa, Takunori, Tanigaki, Tomomi, Serizawa, Yusuke, Nishimura, Masashi, Igarashi, Shunya, Kato, Yoshiki, Kawana, Akihiko, Kimizuka, Yoshifumi
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2023
Karger Publishers
Subjects
Antigens
Cancer therapies
Case Report
Case reports
Chemotherapy
Conflicts of interest
Cysts
diffuse cystic lung metastasis
Kinases
Lung cancer
Lung diseases
Medical imaging
Metastasis
Mutation
non-small-cell lung cancer
osimertinib
Patients
Pneumothorax
Targeted cancer therapy
Tomography
Non-small-cell lung cancer
Osimertinib
Diffuse cystic lung metastasis
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Summary:Abstract Introduction: Diffuse lung cysts occur owing to several diseases; however, diffuse cystic lung metastases are very rare in the case of lung cancer. We report a rare case of diffuse cystic lung metastases from lung adenocarcinoma and reviewed previously reported cases of cystic lung metastases for lung cancer and determined their characteristics. Case Presentation: A 78-year-old Japanese woman with advanced lung adenocarcinoma was positive for the epidermal growth factor receptor gene mutation exon 21 L858R and had been treated with osimertinib. She presented with multiple bilaterally positioned thin-walled lung cysts and pneumothorax. Lung cysts were diagnosed as cystic lung metastases from lung cancer, and carboplatin, pemetrexed, and pembrolizumab were subsequently administered. All cysts markedly decreased in size, and some disappeared. Conclusion: Effective treatment methods for cystic lung metastases from lung cancer have not been reported. To our knowledge, this is the first case of cystic lung metastases that were successfully treated with chemotherapy.
ISSN:1662-6575
1662-6575
DOI:10.1159/000534711