Cancer risk in second degree relatives of children with soft tissue sarcoma

• Published in: British journal of cancer Vol. 63; no. 6; pp. 959 - 962
• Main Authors: HARTLEY, A. L, BIRCH, J. M, TEARE, M. D, BLAIR, V, KELSEY, A. M
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.06.1991
• Subjects: Adolescent; Age Factors; Biological and medical sciences; Child; Dermatology; England; Family; Female; Humans; Male; Medical sciences; Neoplasms - epidemiology; Neoplasms - genetics; Registries; Risk Factors; Sarcoma - epidemiology; Sarcoma - genetics; Sex Characteristics; Soft Tissue Neoplasms - epidemiology; Soft Tissue Neoplasms - genetics; Tumors of the skin and soft tissue. Premalignant lesions; England; Human; Skin disease; Sarcoma; Family study; Parent; Risk factor; Tumor; Soft tissue; Malignant tumor; Child; Genetic disease
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.1991.209

The risk of cancer in the second degree relatives of a population-based series of children with soft tissue sarcoma was studied in relation to (i) various characteristics in these relatives, (ii) certain clinical features in the index children previously identified as risk factors for cancer in their first degree relatives. Overall there was a non-significant deficit of cancers in the second degree relatives (RR = 0.88) and cancer risk was unrelated to type or site of cancer, type of relative, or to risk factors in the index case. The findings indicate that although the families investigated may include a proportion with the Li-Fraumeni cancer family syndrome, the increased cancer risk already reported in the first degree relatives does not extent to second degree relatives in general.