Accelerated Alveolar Bone Loss in Mice Lacking Interleukin-10
Interleukin-10 regulates pro-inflammatory cytokines, including those implicated in alveolar bone resorption. We hypothesized that lack of interleukin-10 leads to increased alveolar bone resorption. Male interleukin-10(−/−) mice, on 129/SvEv and C57BL/6J background, were compared with age-, sex-, and...
Saved in:
Published in | Journal of dental research Vol. 82; no. 8; pp. 632 - 635 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
SAGE Publications
01.08.2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Interleukin-10 regulates pro-inflammatory cytokines, including those implicated in
alveolar bone resorption. We hypothesized that lack of interleukin-10 leads to
increased alveolar bone resorption. Male interleukin-10(−/−) mice, on 129/SvEv and
C57BL/6J background, were compared with age-, sex-, and strain-matched
interleukin-10(+/+) controls for alveolar bone loss. Immunoblotting was used for
analysis of serum reactivity against bacteria associated with colitis and
periodontitis. Interleukin-10(−/−) mice had significantly greater alveolar bone loss
than interleukin-10(+/+) mice (p = 0.006). The 30–40% greater alveolar bone loss in
interleukin-10(−/−) mice was evident in both strains, with C57BL/6J
interleukin-10(−/−) mice exhibiting the most bone loss. Immunoblotting revealed
distinct interleukin-10(−/−) serum reactivity against Bacteroides vulgatus, B. fragilis, Prevotella intermedia, and, to a
lesser extent, against B. forsythus. The results of the
present study suggest that lack of interleukin-10 leads to accelerated alveolar bone
loss. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-0345 1544-0591 |
DOI: | 10.1177/154405910308200812 |