Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia

• Published in: The New England journal of medicine Vol. 389; no. 10; pp. 899 - 910
• Main Authors: Chiesa, Robert, Georgiadis, Christos, Syed, Farhatullah, Zhan, Hong, Etuk, Annie, Gkazi, Soragia Athina, Preece, Roland, Ottaviano, Giorgio, Braybrook, Toni, Chu, Jan, Kubat, Agnieszka, Adams, Stuart, Thomas, Rebecca, Gilmour, Kimberly, O’Connor, David, Vora, Ajay, Qasim, Waseem
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 07.09.2023
• Subjects: Acute lymphoblastic leukemia; Adolescent; Allergy; Allografts; Antigens; Antigens, CD19; Antigens, CD7; Automation; Bone marrow; Cancer; CD52 Antigen; CD7 antigen; Child; Childhood Cancer; Childhood Diseases; Children; Chimeric antigen receptors; Chromosome aberrations; Chromosome translocations; CRISPR; Cytokines; Cytosine; Deamination; DNA damage; Female; Flow cytometry; Genetics; Genetics General; Genomes; Graft versus host disease; Graft-versus-host reaction; Hematology; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Immunology; Immunotherapy; Immunotherapy, Adoptive - adverse effects; Leukemia; Lymphatic leukemia; Lymphocytes; Lymphocytes T; Lymphoma; Medical research; Neurotoxicity; Oncology; Oncology General; Patients; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Proteins; R&D; Receptors, Antigen, T-Cell - genetics; Recurrence; Remission; Remission (Medicine); Research & development; Stem Cell Transplantation; T cell receptors; T-Cells; T-Lymphocytes; Thymine; Transplants & implants; Treatments in Oncology; United Kingdom > UK
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2300709

Three patients with T-cell ALL were treated with allogeneic CAR T cells that were base-edited to prevent CAR T-cell fratricide and graft-versus-host disease and to evade lymphodepleting serotherapy.